8.6.1 ABSTRACT The Women's Cancer Program, led by Douglas Yee, M.D. and Levi Downs, M.D., has 32 members, representing 13 departments and four schools. As of September 30, 2007, these members have a total of $6.6 million in peer reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 281 publications, of which 18% were intra-programmatic and 17% were interprogrammatic. This program was created by combining the members of the Breast Cancer program with new members interested in gynecologic malignancies. By creating the Women's Cancer program, we strengthened existing collaborations, enhanced the interaction between members performing similarly themed research, provided additional scientific mentorship for clinical investigators, and enhanced our capacity for translational research. The scientific goals of the program are to improve detection and prevention strategies, study mechanisms basic to cancer biology, translate research findings into innovative clinical strategies. To achieve these goals, the program is organized into four research themes: 1) functional imaging for cancer diagnosis, staging, and prediction of response to therapy, 2) angiogensis in breast and ovarian cancer, 3) gene expression, cell signaling, and steroid hormone receptor biology, and 4) translational research in cancer prevention and treatmet.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA077598-14S2
Application #
8533470
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
14
Fiscal Year
2012
Total Cost
$1,776
Indirect Cost
$600
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Pang, Jiuxia; Shen, Na; Yan, Fei et al. (2017) Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget 8:34453-34467
Lin, Weiming; Modiano, Jaime F; Ito, Daisuke (2017) Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells. J Vet Sci 18:101-104
Winterhoff, Boris J; Maile, Makayla; Mitra, Amit Kumar et al. (2017) Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells. Gynecol Oncol 144:598-606
Jaramillo, Ericka G; Mupere, Ezekiel; Opoka, Robert O et al. (2017) Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency. PLoS One 12:e0183977
Zhao, Xianda; Li, Lihua; Starr, Timothy K et al. (2017) Tumor location impacts immune response in mouse models of colon cancer. Oncotarget 8:54775-54787
Lynn, Geoffrey E; Oliver, Jonathan D; Cornax, Ingrid et al. (2017) Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent. Parasit Vectors 10:48
Luangphakdy, Viviane; Elizabeth Pluhar, G; Piuzzi, Nicolás S et al. (2017) The Effect of Surgical Technique and Spacer Texture on Bone Regeneration: A Caprine Study Using the Masquelet Technique. Clin Orthop Relat Res 475:2575-2585
Boylan, Kristin L M; Buchanan, Petra C; Manion, Rory D et al. (2017) The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget 8:9717-9738
Mallhi, K; Orchard, P J; Miller, W P et al. (2017) Non-myeloablative conditioning for second hematopoietic cell transplantation for graft failure in patients with non-malignant disorders: a prospective study and review of the literature. Bone Marrow Transplant 52:726-732
Richardson, Paul G; Smith, Angela R; Triplett, Brandon M et al. (2017) Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. Br J Haematol 178:112-118

Showing the most recent 10 out of 957 publications