8.7.1 ABSTRACT: TRANSPLANT BIOLOGY AND THERAPY The Transplant Biology and Therapy (TBT) Program, is a long-established group representing over 30 years of collaborative translational investigation. Led by Daniel Weisdorf, M.D. and John E.. Wagner, M.D., the TBT Program has 38 members, representing investigators affiliated with seven departments and Institutes within schools (Medical School, College of Pharmacy, School of Public Health). As of October 1, 2007, members had 61 distinct (27 peer-reviewed;34 other) externally funded research grants providing a total of $15.3 million in total support for the current budget period (: Since June 2003, their research has resulted in 288 publications, of which 47% were intra-programrriatic and 18% were inter-programmatic. The central research themes of the program include hematopoietic and noh-hematopoietic stem cell biology, hematopoietic cell transplant (HCT), immuriobiology and immune-based therapies as well as studies of tissue repair, peri-transplant complications, survivorship/late effects and quality of life. The Program emphasizes translational development of new agents for therapeutic application and testing in phase l-ll clinical trials with a future goal of moving Cancer Center investigator-initiated phase I and II studies to definitive, multi-institutional phase III clinical trials. The scientific goals of the program are to advance knowledge of human hematopoietic and non-hematopoietic stem cells and derivative populations, advance the understanding of innate and adaptive immunity and immune reconstitution and its use for therapy in conjunction with HCT, develop novel therapeutic approaches to eliminate or reduce the transplantassociated risks of graft failure, acute and chronic graft-versus-host disease (GVHD), opportunistic infection and relapse, and improve the short and long-term quality of life in HCT survivors. Since its inception in 1974, the TBT Program has been a world leader in the field, advancing and improving the effectiveness of transplant therapy through basic and translational research that is ultimately applied to the care of patients. TBT Program investigators use all resources of the University of Minnesota Cancer Center to advance both clinical and basic laboratory investigations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA077598-14S2
Application #
8533471
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
14
Fiscal Year
2012
Total Cost
$1,776
Indirect Cost
$600
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Pang, Jiuxia; Shen, Na; Yan, Fei et al. (2017) Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget 8:34453-34467
Lin, Weiming; Modiano, Jaime F; Ito, Daisuke (2017) Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells. J Vet Sci 18:101-104
Winterhoff, Boris J; Maile, Makayla; Mitra, Amit Kumar et al. (2017) Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells. Gynecol Oncol 144:598-606
Jaramillo, Ericka G; Mupere, Ezekiel; Opoka, Robert O et al. (2017) Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency. PLoS One 12:e0183977
Zhao, Xianda; Li, Lihua; Starr, Timothy K et al. (2017) Tumor location impacts immune response in mouse models of colon cancer. Oncotarget 8:54775-54787
Lynn, Geoffrey E; Oliver, Jonathan D; Cornax, Ingrid et al. (2017) Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent. Parasit Vectors 10:48
Luangphakdy, Viviane; Elizabeth Pluhar, G; Piuzzi, Nicolás S et al. (2017) The Effect of Surgical Technique and Spacer Texture on Bone Regeneration: A Caprine Study Using the Masquelet Technique. Clin Orthop Relat Res 475:2575-2585
Boylan, Kristin L M; Buchanan, Petra C; Manion, Rory D et al. (2017) The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget 8:9717-9738
Mallhi, K; Orchard, P J; Miller, W P et al. (2017) Non-myeloablative conditioning for second hematopoietic cell transplantation for graft failure in patients with non-malignant disorders: a prospective study and review of the literature. Bone Marrow Transplant 52:726-732
Richardson, Paul G; Smith, Angela R; Triplett, Brandon M et al. (2017) Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. Br J Haematol 178:112-118

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