9.7.1 ABSTRACT: TISSUE PROCUREMENT FACILITY Director: Amy Skubitz .. ? The mission of the Tissue Procurement Facility (hereafter abbreviated TPF) is to procure samples from? . patients in support of basic, translational;and clinical cancer researchers at the University of Minnesota ' Cancer Center who are currently funded by national peer-reviewed agencies. Our goal is to develop a repository of patient-derived specimens including well preserved samples of malignant and benign tumors, rare tumors, organ matched normal tissue, and when possible, unrelated normal tissues. The TPF is a centralized resource thatcontrols for: standardization of tissue sample processing, storage, quality control, distribution, patient consent, and record maintenance. The TPF has office and laboratory space which is . , contiguous with Surgical Pathology's frozen satellite area and operating rooms of the University of Minnesota MedicalCenter, Fairview. The TPF has two liquid nitrogen freezers and one -80C freezer,with aooxygen ?. sensor and an alarm system. Acryostatand microtome areavailable for hourly .usage by researchers. The TPF works seamlessly with the activities of 'the Surgical Pathology Division, such that waste tissues are ? processed by: (a) freezing in liquid nitrogen;(b) embedding in a cryopreservative, then freezing at -80?C;(c) . fixing in formalin, then embedding in paraffin;and (d) maintaining as fresh tissue foYimmediate use: We ensure that all patients sign our consent form prior to our procurement of their waste tissue, which may . include solid tumors, normal solid tissue, blood, urine, saliva, and ascites fluid. In addition, we """"""""custom design"""""""" the way tissue specimens are procured in order to fulfill the Individual requests of each of the Cancer Center members. In order to meet the increasing tissue needs of Cancer Center members, we plan to expand our services to procure cytology specimens, (including pancreatic fine needle aspiration specimens, pleural fluid, and ascites fluid). Wewill also provide researchers with tissue microarrays and perform laser, . capture microdissection and immunohistochemical staining of samples

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA077598-14S2
Application #
8533478
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
14
Fiscal Year
2012
Total Cost
$1,775
Indirect Cost
$599
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Pang, Jiuxia; Shen, Na; Yan, Fei et al. (2017) Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget 8:34453-34467
Lin, Weiming; Modiano, Jaime F; Ito, Daisuke (2017) Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells. J Vet Sci 18:101-104
Winterhoff, Boris J; Maile, Makayla; Mitra, Amit Kumar et al. (2017) Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells. Gynecol Oncol 144:598-606
Jaramillo, Ericka G; Mupere, Ezekiel; Opoka, Robert O et al. (2017) Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency. PLoS One 12:e0183977
Zhao, Xianda; Li, Lihua; Starr, Timothy K et al. (2017) Tumor location impacts immune response in mouse models of colon cancer. Oncotarget 8:54775-54787
Lynn, Geoffrey E; Oliver, Jonathan D; Cornax, Ingrid et al. (2017) Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent. Parasit Vectors 10:48
Luangphakdy, Viviane; Elizabeth Pluhar, G; Piuzzi, Nicolás S et al. (2017) The Effect of Surgical Technique and Spacer Texture on Bone Regeneration: A Caprine Study Using the Masquelet Technique. Clin Orthop Relat Res 475:2575-2585
Boylan, Kristin L M; Buchanan, Petra C; Manion, Rory D et al. (2017) The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget 8:9717-9738
Mallhi, K; Orchard, P J; Miller, W P et al. (2017) Non-myeloablative conditioning for second hematopoietic cell transplantation for graft failure in patients with non-malignant disorders: a prospective study and review of the literature. Bone Marrow Transplant 52:726-732
Richardson, Paul G; Smith, Angela R; Triplett, Brandon M et al. (2017) Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. Br J Haematol 178:112-118

Showing the most recent 10 out of 957 publications