8.3.1 ABSTRACT: GENETIC MECHANISMS OF CANCER The Genetic Mechanisms of Cancer program, lead by David Largaespada, has 40 members, representing ten departments and three schools. As of September 30,2007, these members have a total of $10.9 million in peer-reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 234 publications, of which 17% were intra-prograrnmatic and 15% were inter-programmatic. The Genetic Mechanisms of Cancer research program focuses on gene discovery, stability, expression, and transfer. - . . '? ?;. . ... . Dr. Largaespada is the Margaret Harvey Schering Land Grant Chair in Cancer Genetics. He is the director of the Mouse Genetics Laboratory shared resource of the Cancer Center. As chair of the Rodent Advisory Committee, he plays a role in advising the Academic Health Center on issues related to mouse and rat work at the University of Minnesota. He is a member of the NCI-sponsored Mouse Models of Human Cancer Consortium. The program also includes scientists with leadership positions in clinical research. Dr. Robert Kratzke, who is the Vice Chair of the Respiratory Committee of the Cancer and Leukemia Group B T (CALGB), as well as Chair of the Respiratory Working Group (RWG) for Correlative Sciences. Dr. Robert Madoff is on the gastrointestinal subcommittee of the CALGB and board of directors of the Minnesota Colorectal Cancer Initiative. Other program members have important leadership roles within the University of Minnesota. Dr. Brian Van Ness is the chair of the Department of Genetics, Cell Biology and Development. Dr. Scott Selleck is the director of the Developmental Biology Center. Dr. Harry Orr js the Tulloch Professor of Genetics, the director of the Institute of Human Genetics (IHG), and a Special Advisor to the Dean of the Medical School on basic science matters. Dr.
J aim e Modiano is the director of the Animal Cancer Center in the Veterinary Medical Center and holds the Al and June Perlman Endowed Chair in Animal Oncology.
|Pierpont, Elizabeth I; Hudock, Rebekah L; Foy, Allison M et al. (2018) Social skills in children with RASopathies: a comparison of Noonan syndrome and neurofibromatosis type 1. J Neurodev Disord 10:21|
|Carlson, Erik S; Upadhyaya, Pramod; Villalta, Peter W et al. (2018) Analysis and Identification of 2'-Deoxyadenosine-Derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-p Chem Res Toxicol 31:358-370|
|Lin, Lifeng; Chu, Haitao; Murad, Mohammad Hassan et al. (2018) Empirical Comparison of Publication Bias Tests in Meta-Analysis. J Gen Intern Med 33:1260-1267|
|Rashidi, Armin; Ebadi, Maryam; Said, Bassil et al. (2018) Absence of early HHV-6 reactivation after cord blood allograft predicts powerful graft-versus-tumor effect. Am J Hematol :|
|Bejanyan, Nelli; Brunstein, Claudio G; Cao, Qing et al. (2018) Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD. Blood Adv 2:909-922|
|Bachanova, Veronika; Sarhan, Dhifaf; DeFor, Todd E et al. (2018) Haploidentical natural killer cells induce remissions in non-Hodgkin lymphoma patients with low levels of immune-suppressor cells. Cancer Immunol Immunother 67:483-494|
|Hupp, Meghan; Williams, Sarah; Dunnette, Brian et al. (2018) Comparison of evaluation techniques, including digital image analysis, for MYC protein expression by immunohistochemical stain in aggressive B-cell lymphomas. Hum Pathol :|
|Rashidi, Armin; Shanley, Ryan; Holtan, Shernan G et al. (2018) Pretransplant Serum Citrulline Predicts Acute Graft-versus-Host Disease. Biol Blood Marrow Transplant 24:2190-2196|
|Ma, Bin; Zarth, Adam T; Carlson, Erik S et al. (2018) Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chem Res Toxicol 31:48-57|
|Hatsukami, Dorothy K; Luo, Xianghua; Jensen, Joni A et al. (2018) Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. JAMA 320:880-891|
Showing the most recent 10 out of 1013 publications