8.5.1 ABSTRACT: IMMUNOLOGY The Immunology program, lead by Yoji Shimizu, Ph.D., has 16 members, representing seven departments and three schools. As of September 30,2007, these members have a total of $8.1 million in peer-reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 163 publications, of which 15% were intra-programmatic and 28% were inter-programmatic. The scientific goals of the program are to elucidate the basic mechanisms that underlie the development and function of the immune system, and to use this information to enhance the evaluation, development and implementation of effective anti-cancer immunotherapies. Research activities in the program are focused on four research themes: mechanisms, of lymphocyte tolerance, lymphocyte activation and signal transduction, lymphocyte development, and tumor immunology/immunotherapy. Significant strength in cellular and molecular immunology has allowed Immunology program investigators to develop novel technical approaches for the analysis and quantitation of the immune response in vivo that have led to seminal insights into the development and function of the adaptive immune response. Intra-programmatic collaborations are facilitated by regular group meetings, common research space for program investigators, and a NIH-funded program project on peripheral tolerance. Intra-programmatic and inter-programmatic collaborations, coupled with new faculty recruitment, have enhanced translational research activities within the program. These activities have allowed program investigators to utilize basic research insights obtained within the program as a foundation for the development and testing of specific immunotherapeutic approaches designed to enhance the immune response to cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Minnesota Twin Cities
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Abbott, Kenneth L; Nyre, Erik T; Abrahante, Juan et al. (2015) The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res 43:D844-8
Yee, Douglas (2015) A tale of two receptors: insulin and insulin-like growth factor signaling in cancer. Clin Cancer Res 21:667-9
Daniel, A R; Gaviglio, A L; Knutson, T P et al. (2015) Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene 34:506-15
Upadhyaya, Pramod; Hecht, Stephen S (2015) Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine Tob Res 17:524-9
Patel, Yesha M; Stram, Daniel O; Wilkens, Lynne R et al. (2015) The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev 24:119-27
Takahashi, Yutaka; Hui, Susanta K (2014) Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy. Radiat Oncol 9:34
Cooley, Sarah; Weisdorf, Daniel J; Guethlein, Lisbeth A et al. (2014) Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia. J Immunol 192:4592-600
Chen, Liddy M; Ibrahim, Joseph G; Chu, Haitao (2014) Flexible stopping boundaries when changing primary endpoints after unblinded interim analyses. J Biopharm Stat 24:817-33
Landman, Sean R; Hwang, Tae Hyun; Silverstein, Kevin A T et al. (2014) SHEAR: sample heterogeneity estimation and assembly by reference. BMC Genomics 15:84
Gates, Leah A; Phillips, Martin B; Matter, Brock A et al. (2014) Comparative metabolism of furan in rodent and human cryopreserved hepatocytes. Drug Metab Dispos 42:1132-6

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