9.1.1 ABSTRACT: ANALYTICAL BIOCHEMISTRY Director: Stephen S. Hecht, Ph.D. The mission of the Analytical Biochemistry Shared Resource is to provide high quality analytical services, using state of the art chromatographic, mass spectrometric, and related techniques, to members of the Cancer Center, promptly and at low cost. There are 3 major services: mass spectrometry;biomarker applications, particularly with respect to tobacco use;and instrument maintenance and service. This resource continues to be an outstanding and extensively used facility in support of studies on chemical aspects of carcinogenesis and biomarker development and application, particularly by investigators in the Carcinogenesis and Chemoprevention, and Prevention and Etiology programs. The mass spectrometry service is absolutely critical to many ongoing studies in the Cancer Center. The tobacco carcinogen biomarker services are internationally known and are frequently used by investigators outside of the Cancer Center. The instrument maintenance activity is unique and saves time and precious resources. One great asset of this Shared Resource is the expertise of its members. Stephen Hecht, Sharon Murphy, Peter Villalta, and Steven Carmella have nearly 100 years of combined expertise in analytical biochemistry, mass spectrometry, structure determination, and chromatographic instrumentation. Members of the Cancer Center continually call on these individuals for guidance in analytical biochemistry-related projects, methods development, and instrument trouble-shooting. This heavily used and technically outstanding facility continues to provide crucial services to its highly productive users.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA077598-15
Application #
8449993
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
15
Fiscal Year
2013
Total Cost
$91,758
Indirect Cost
$30,991
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Sarver, Aaron L; Murray, Collin D; Temiz, Nuri A et al. (2016) MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer. Cell Cycle 15:881-5
Diep, Caroline H; Knutson, Todd P; Lange, Carol A (2016) Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. Mol Cancer Res 14:141-62
Yun, Young Sung; Kim, Kwan Hyun; Tschida, Barbara et al. (2016) mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress. Mol Cell 61:625-39
Yan, Y; Hanse, E A; Stedman, K et al. (2016) Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells. Cell Death Differ 23:1232-42
Beura, Lalit K; Hamilton, Sara E; Bi, Kevin et al. (2016) Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532:512-6
Than, B L N; Linnekamp, J F; Starr, T K et al. (2016) CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene 35:4179-87
Struntz, Nicholas B; Harki, Daniel A (2016) Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors. ACS Chem Biol 11:1631-8
Knorr, David A; Wang, Hongbo; Aurora, Mukta et al. (2016) Loss of T Follicular Helper Cells in the Peripheral Blood of Patients with Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant 22:825-33
Glasgow, Michelle; Vogel, Rachel Isaksson; Burgart, Jennifer et al. (2016) Long term follow-up of a phase II trial of multimodal therapy given in a "sandwich" method for stage III, IV, and recurrent endometrial cancer. Gynecol Oncol Res Pract 3:6
Felices, Martin; Lenvik, Todd R; Davis, Zachary B et al. (2016) Generation of BiKEs and TriKEs to Improve NK Cell-Mediated Targeting of Tumor Cells. Methods Mol Biol 1441:333-46

Showing the most recent 10 out of 763 publications