9.2.1 ABSTRACT: COMPARATIVE PATHOLOGY Director: Cathy S. Carlson, DVM, PhD, Diplomats ACVP The Comparative Pathology Shared Resource provides expert veterinary pathology support for Cancer Center members who use laboratory animals in their research. Three full-time histotechnicians provide services that include generation of histolpgical sections from frozen and formalin fixed tissues, detection of antigens by immunohistochemistry, and development of new immunohistochemical protocols. Four boardcertified veterinary pathologists provide assistance with project design, evaluation of gross lesions, interpretation of changes in histological sections (both routine sections and immunohistbchemistry preparations), immunohistochemistry technique development, and imaging services. In the next grant cycle, histomorphometry services that will allow quantitation of gross and microscopic tissue changes as well as quantitation of immunohistochemistry results will be included. Having a dedicated group of veterinary pathologists with research expertise available to assist Cancer Center investigators with projects involving animal tissues provides a critical resource for some projects and is essential for publications involving pathological changes in tissues. The marked growth of this resource over the past 5 years is a testament to its value to the Cancer Center. Its location in the College of Veterinary Medicine at the University of Minnesota is easily accessible to Cancer Center investigators. Submission of samples and communication of results is further facilitated by a courier service, electronic communications, and the weekly on-site availability of one of the pathologists at the Cancer Center for consultation on projects. Cancer Center members are given priority for all services offered by the shared resource. Although projects are usually done on a first-come, first-served basis, an advisory board is in place to provide advice regarding prioritization of projects when this is needed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA077598-15
Application #
8449995
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
15
Fiscal Year
2013
Total Cost
$101,440
Indirect Cost
$34,261
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Abbott, Kenneth L; Nyre, Erik T; Abrahante, Juan et al. (2015) The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res 43:D844-8
Yee, Douglas (2015) A tale of two receptors: insulin and insulin-like growth factor signaling in cancer. Clin Cancer Res 21:667-9
Daniel, A R; Gaviglio, A L; Knutson, T P et al. (2015) Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene 34:506-15
Upadhyaya, Pramod; Hecht, Stephen S (2015) Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine Tob Res 17:524-9
Patel, Yesha M; Stram, Daniel O; Wilkens, Lynne R et al. (2015) The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev 24:119-27
Takahashi, Yutaka; Hui, Susanta K (2014) Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy. Radiat Oncol 9:34
Cooley, Sarah; Weisdorf, Daniel J; Guethlein, Lisbeth A et al. (2014) Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia. J Immunol 192:4592-600
Chen, Liddy M; Ibrahim, Joseph G; Chu, Haitao (2014) Flexible stopping boundaries when changing primary endpoints after unblinded interim analyses. J Biopharm Stat 24:817-33
Landman, Sean R; Hwang, Tae Hyun; Silverstein, Kevin A T et al. (2014) SHEAR: sample heterogeneity estimation and assembly by reference. BMC Genomics 15:84
Gates, Leah A; Phillips, Martin B; Matter, Brock A et al. (2014) Comparative metabolism of furan in rodent and human cryopreserved hepatocytes. Drug Metab Dispos 42:1132-6

Showing the most recent 10 out of 319 publications