9.2.1 ABSTRACT: COMPARATIVE PATHOLOGY Director: Cathy S. Carlson, DVM, PhD, Diplomats ACVP The Comparative Pathology Shared Resource provides expert veterinary pathology support for Cancer Center members who use laboratory animals in their research. Three full-time histotechnicians provide services that include generation of histolpgical sections from frozen and formalin fixed tissues, detection of antigens by immunohistochemistry, and development of new immunohistochemical protocols. Four boardcertified veterinary pathologists provide assistance with project design, evaluation of gross lesions, interpretation of changes in histological sections (both routine sections and immunohistbchemistry preparations), immunohistochemistry technique development, and imaging services. In the next grant cycle, histomorphometry services that will allow quantitation of gross and microscopic tissue changes as well as quantitation of immunohistochemistry results will be included. Having a dedicated group of veterinary pathologists with research expertise available to assist Cancer Center investigators with projects involving animal tissues provides a critical resource for some projects and is essential for publications involving pathological changes in tissues. The marked growth of this resource over the past 5 years is a testament to its value to the Cancer Center. Its location in the College of Veterinary Medicine at the University of Minnesota is easily accessible to Cancer Center investigators. Submission of samples and communication of results is further facilitated by a courier service, electronic communications, and the weekly on-site availability of one of the pathologists at the Cancer Center for consultation on projects. Cancer Center members are given priority for all services offered by the shared resource. Although projects are usually done on a first-come, first-served basis, an advisory board is in place to provide advice regarding prioritization of projects when this is needed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA077598-15
Application #
8449995
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
15
Fiscal Year
2013
Total Cost
$101,440
Indirect Cost
$34,261
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Xu, Bin; Magli, Alessandro; Anugrah, Yoska et al. (2018) Nanotopography-responsive myotube alignment and orientation as a sensitive phenotypic biomarker for Duchenne Muscular Dystrophy. Biomaterials 183:54-66
Nikodemova, Maria; Yee, Jeremiah; Carney, Patrick R et al. (2018) Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. Environ Int 113:249-258
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Mondragon-Gonzalez, Ricardo; Perlingeiro, Rita C R (2018) Recapitulating muscle disease phenotypes with myotonic dystrophy 1 induced pluripotent stem cells: a tool for disease modeling and drug discovery. Dis Model Mech 11:
Kim, J-H; Frantz, A M; Sarver, A L et al. (2018) Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Vet Comp Oncol 16:E176-E184
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Lin, Lifeng; Chu, Haitao; Murad, Mohammad Hassan et al. (2018) Empirical Comparison of Publication Bias Tests in Meta-Analysis. J Gen Intern Med 33:1260-1267

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