9.7.1 ABSTRACT: TISSUE PROCUREMENT FACILITY Director: Amy Skubitz .. ? The mission of the Tissue Procurement Facility (hereafter abbreviated TPF) is to procure samples from? . patients in support of basic, translational;and clinical cancer researchers at the University of Minnesota ' Cancer Center who are currently funded by national peer-reviewed agencies. Our goal is to develop a repository of patient-derived specimens including well preserved samples of malignant and benign tumors, rare tumors, organ matched normal tissue, and when possible, unrelated normal tissues. The TPF is a centralized resource thatcontrols for: standardization of tissue sample processing, storage, quality control, distribution, patient consent, and record maintenance. The TPF has office and laboratory space which is . , contiguous with Surgical Pathology's frozen satellite area and operating rooms of the University of Minnesota MedicalCenter, Fairview. The TPF has two liquid nitrogen freezers and one -80C freezer,with aooxygen ?. sensor and an alarm system. Acryostatand microtome areavailable for hourly .usage by researchers. The TPF works seamlessly with the activities of 'the Surgical Pathology Division, such that waste tissues are ? processed by: (a) freezing in liquid nitrogen;(b) embedding in a cryopreservative, then freezing at -80?C;(c) . fixing in formalin, then embedding in paraffin;and (d) maintaining as fresh tissue foYimmediate use: We ensure that all patients sign our consent form prior to our procurement of their waste tissue, which may . include solid tumors, normal solid tissue, blood, urine, saliva, and ascites fluid. In addition, we """"""""custom design"""""""" the way tissue specimens are procured in order to fulfill the Individual requests of each of the Cancer Center members. In order to meet the increasing tissue needs of Cancer Center members, we plan to expand our services to procure cytology specimens, (including pancreatic fine needle aspiration specimens, pleural fluid, and ascites fluid). Wewill also provide researchers with tissue microarrays and perform laser, . capture microdissection and immunohistochemical staining of samples

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National Cancer Institute (NCI)
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Subcommittee G - Education (NCI)
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Pierpont, Elizabeth I; Hudock, Rebekah L; Foy, Allison M et al. (2018) Social skills in children with RASopathies: a comparison of Noonan syndrome and neurofibromatosis type 1. J Neurodev Disord 10:21
Carlson, Erik S; Upadhyaya, Pramod; Villalta, Peter W et al. (2018) Analysis and Identification of 2'-Deoxyadenosine-Derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-p Chem Res Toxicol 31:358-370
Lin, Lifeng; Chu, Haitao; Murad, Mohammad Hassan et al. (2018) Empirical Comparison of Publication Bias Tests in Meta-Analysis. J Gen Intern Med 33:1260-1267
Rashidi, Armin; Ebadi, Maryam; Said, Bassil et al. (2018) Absence of early HHV-6 reactivation after cord blood allograft predicts powerful graft-versus-tumor effect. Am J Hematol :
Bejanyan, Nelli; Brunstein, Claudio G; Cao, Qing et al. (2018) Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD. Blood Adv 2:909-922
Bachanova, Veronika; Sarhan, Dhifaf; DeFor, Todd E et al. (2018) Haploidentical natural killer cells induce remissions in non-Hodgkin lymphoma patients with low levels of immune-suppressor cells. Cancer Immunol Immunother 67:483-494
Hupp, Meghan; Williams, Sarah; Dunnette, Brian et al. (2018) Comparison of evaluation techniques, including digital image analysis, for MYC protein expression by immunohistochemical stain in aggressive B-cell lymphomas. Hum Pathol :
Rashidi, Armin; Shanley, Ryan; Holtan, Shernan G et al. (2018) Pretransplant Serum Citrulline Predicts Acute Graft-versus-Host Disease. Biol Blood Marrow Transplant 24:2190-2196
Ma, Bin; Zarth, Adam T; Carlson, Erik S et al. (2018) Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chem Res Toxicol 31:48-57
Hatsukami, Dorothy K; Luo, Xianghua; Jensen, Joni A et al. (2018) Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. JAMA 320:880-891

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