BIOSTATISTICS AND INFORMATICS Director: Chap T. Le, Ph.D. The primary objective of the Biostatistics and Informatics shared resource of the University of Minnesota Cancer Center is to provide centralized biostatistics and bioinfofmatics services, collaborative research and data management support for the research projects of all members of the University of Minnesota Cancer Center. This resource serves as the focal point from which investigators and their team members and/or associates at the University of Minnesota Cancer Center can draw biostatistics and bioinformatics expertise for the design, data management and analysis of their research projects.
The specific aims of the core are to provide: biostatistics and bioinformatics expertise in study design, including endpoint definition, sample size estimation and power calculation, randomization procedures, data collection form design, plans for report generation, interim reviews, and final analysis; biostatistics and bioinformatics analyses and informatics support for all cancer research projects using contemporary statistical and computing methodologies;and data management support for the development and management of all research projects, as well as research-specific databases by all investigators and their team and/or associates at the University of Minnesota Cancer Center. Biostatistics and Informatics is a shared resource of the University of Minnesota Cancer Center;it may draw more support from faculty of the Division of Biostatistics, School of Public Health, if and when heeded;but it is operating within the Cancer Center, independent of the Division of Biostatistics. All members, research programs and other shared resourcess of the University of Minnesota Cancer Center are supported by Biostatistics and Informatics.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
United States
Zip Code
Abbott, Kenneth L; Nyre, Erik T; Abrahante, Juan et al. (2015) The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res 43:D844-8
Yee, Douglas (2015) A tale of two receptors: insulin and insulin-like growth factor signaling in cancer. Clin Cancer Res 21:667-9
Daniel, A R; Gaviglio, A L; Knutson, T P et al. (2015) Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene 34:506-15
Upadhyaya, Pramod; Hecht, Stephen S (2015) Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine Tob Res 17:524-9
Patel, Yesha M; Stram, Daniel O; Wilkens, Lynne R et al. (2015) The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev 24:119-27
Chen, Liddy M; Ibrahim, Joseph G; Chu, Haitao (2014) Flexible stopping boundaries when changing primary endpoints after unblinded interim analyses. J Biopharm Stat 24:817-33
Takahashi, Yutaka; Hui, Susanta K (2014) Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy. Radiat Oncol 9:34
Cooley, Sarah; Weisdorf, Daniel J; Guethlein, Lisbeth A et al. (2014) Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia. J Immunol 192:4592-600
Gorden, Brandi H; Kim, Jong-Hyuk; Sarver, Aaron L et al. (2014) Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization. Am J Pathol 184:985-95
Landman, Sean R; Hwang, Tae Hyun; Silverstein, Kevin A T et al. (2014) SHEAR: sample heterogeneity estimation and assembly by reference. BMC Genomics 15:84

Showing the most recent 10 out of 319 publications