The mission ofthe Comparative Pathology Shared Resource (CPSR) is to provide full-service pathology support for Masonic Cancer Center (MCC) members who use animal subjects in their laboratory and clinical research. CPSR is a critical resource for projects utilizing animal tissues and is essential for publications involving pathological changes in tissues. M. Gerard O'Sullivan, MVB, PhD, took over the leadership of CSPR in 2009;Dr. O'Sullivan has more than 20 years of experience in comparative and experimental veterinary pathology. Also in 2009, CPSR recruited a very experienced histotechnologist, Paula Overn. Three histotechnicians prepare appropriately processed fixed or frozen tissues for histology and immunohistochemistry. Particular strengths ofthe Shared Resource are in doing non-routine challenging or tedious histological preparations that require special handling, such as sectioning and performing immunohistochemistry on bone. Board-certified veterinary pathologists provide expert gross and histopathologic analyses, generate high-resolution digital images of specimens, and provide intellectual input on study design and manuscript preparation for research projects and grant applications. The CPSR also has considerable experience in developing new protocols and techniques and has developed approximately 60 new immunohistochemistry markers since 2008. In addition, the CPSR has developed double-labeling techniques to simultaneously detect several combinations of proteins. Requests for quantification of marker expression and histomorphometric evaluations have increased, and CSPR has gained access to equipment and software to accommodate these requests. Weekly staff meetings and the oversight of an advisory committee composed of CPSR users ensure that the resource is able to meet the needs of MCC members for veterinary pathology.

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National Cancer Institute (NCI)
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Subcommittee G - Education (NCI)
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University of Minnesota Twin Cities
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Winterhoff, Boris J; Maile, Makayla; Mitra, Amit Kumar et al. (2017) Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells. Gynecol Oncol 144:598-606
Jaramillo, Ericka G; Mupere, Ezekiel; Opoka, Robert O et al. (2017) Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency. PLoS One 12:e0183977
Pang, Jiuxia; Shen, Na; Yan, Fei et al. (2017) Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget 8:34453-34467
Lin, Weiming; Modiano, Jaime F; Ito, Daisuke (2017) Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells. J Vet Sci 18:101-104
Luangphakdy, Viviane; Elizabeth Pluhar, G; Piuzzi, Nicolás S et al. (2017) The Effect of Surgical Technique and Spacer Texture on Bone Regeneration: A Caprine Study Using the Masquelet Technique. Clin Orthop Relat Res 475:2575-2585
Boylan, Kristin L M; Buchanan, Petra C; Manion, Rory D et al. (2017) The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget 8:9717-9738
Zhao, Xianda; Li, Lihua; Starr, Timothy K et al. (2017) Tumor location impacts immune response in mouse models of colon cancer. Oncotarget 8:54775-54787
Lynn, Geoffrey E; Oliver, Jonathan D; Cornax, Ingrid et al. (2017) Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent. Parasit Vectors 10:48
Mitchell, Richard; Wagner, John E; Brunstein, Claudio et al. (2017) Impact of Delayed Infusion Time in Umbilical Cord Blood Transplantation. Biol Blood Marrow Transplant 23:836-839
Guspiel, Amanda; Menk, Jeremiah; Streifel, Andrew et al. (2017) Management of Risks From Water and Ice From Ice Machines for the Very Immunocompromised Host: A Process Improvement Project Prompted by an Outbreak of Rapidly Growing Mycobacteria on a Pediatric Hematopoietic Stem Cell Transplant (Hsct) Unit. Infect Control Hosp Epidemiol 38:792-800

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