The Hematopoietic Malignancies Program of the UCSF Helen Diller Family Comprehensive Cancer Center includes 18 members from eight academic departments. The Program is built upon extraordinary institutional strengths in basic and population sciences, outstanding clinical programs for the care of patients with leukemia, lymphoma, and myeloma;and a tradition of cross-disciplinary collaborations in scientific investigations. The Program activities comprise two broad themes: (1) Hematopoiesis and Myeloid Leukemogenesis;and (2) Lymphoid Growth Control and Lymphoid Malignancies. Within these major themes the Program has established a highly interactive interdisciplinary approach that includes efforts directed at: gene discovery;modeling leukemia and lymphoma-associated genetic lesions in the mouse;characterizing signal transduction pathways that are crucial for cellular growth control;testing experimental therapeutics with molecular analysis to ascertain mechanisms of drug action and drug resistance;and defining environmental risk factors that contribute to the development of hematologic cancers. The NCI and other peer-reviewed support for this group of investigators for the 2010-2011 academic year totaled $4,541,421. The Program has 9% intra-programmatic and 12.5% inter-programmatic publications.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA082103-15
Application #
8567875
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
15
Fiscal Year
2013
Total Cost
$96,543
Indirect Cost
$90,775
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Shatsky, Maxim; Dong, Ming; Liu, Haichuan et al. (2016) Quantitative Tagless Copurification: A Method to Validate and Identify Protein-Protein Interactions. Mol Cell Proteomics 15:2186-202
Nordström, Tobias; Van Blarigan, Erin L; Ngo, Vy et al. (2016) Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer. Prostate 76:339-48
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Phan, An T; Fernandez, Samantha G; Somberg, Jessica J et al. (2016) Epstein-Barr virus latency type and spontaneous reactivation predict lytic induction levels. Biochem Biophys Res Commun 474:71-5
Chang, Matthew T; Asthana, Saurabh; Gao, Sizhi Paul et al. (2016) Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. Nat Biotechnol 34:155-63

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