The Cancer Prevention and Control (CPC) Program has evolved to establish strong intra- and inter-programmatic collaborations with all IUSCC Programs (HMI, EDT, TMM, and BCP). The Program's external partnerships with other universities and cancer centers can be traced back to 1995 when Program Leader, Dr. Victoria Champion founded the Behavioral Cooperative Oncology Group (BCOG) a consortium of senior scientists from the University of Michigan, Michigan State, Ohio State, Purdue, and Indiana University whose purpose was to conduct significant and innovative cancer control research and train interdisciplinary future scientists. CPC goals are addressed through three Themes: 1) Prevention, 2) Early Detection, and 3) Survivorship. Each Theme approaches a challenge crucial to decreasing cancer morbidity and mortality. Within Theme 1, CPC researchers study new HPV vaccine delivery methods to enhance global accessibility and work towards decreasing the prevalence of tobacco use through smoking prevention, cessation, and relapse reduction research which is translated into evidence-based interventions for the community. Theme 2 researchers are identifying colorectal cancer (CRC) risk algorithms to aid in selecting appropriate screening tests, and addressing cervical and CRC screening compliance issues. Finally, Theme 3 researchers are evaluating mechanisms and treatment options for prevention of chemotherapy-induced neurotoxicity and cognitive dysfunction, and developing and testing interventions to decrease symptom burden. CPC has 26 full and 11 associate members, representing 13 departments and 9 schools on the campuses of Indiana University School of Medicine (IUSOM), Indiana University-Purdue University Indianapolis (lUPUl) and Notre Dame. The Program has a total of $4.4M in current peer reviewed funding, with $1.8M from the NCI, $1.7M from other NIH branches, $159K in ACS funds, and $744K in other peer-reviewed funding. Over the past funding period, CPC members have authored a total of 311 publications. Of these, 36% represent intra-programmatic collaborations, 14.1% represent inter-programmatic collaborations, and 21.2% represent inter-institutional collaborations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA082709-15
Application #
8781060
Study Section
Subcommittee G - Education (NCI)
Project Start
1999-09-22
Project End
2019-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
15
Fiscal Year
2014
Total Cost
$57,965
Indirect Cost
$23,931
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Broxmeyer, Hal E; Pelus, Louis M (2014) Inhibition of DPP4/CD26 and dmPGE? treatment enhances engraftment of mouse bone marrow hematopoietic stem cells. Blood Cells Mol Dis 53:34-8
Blue, Emily K; DiGiuseppe, Robert; Derr-Yellin, Ethel et al. (2014) Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Pediatr Res 75:266-72
Miller, Kathy D; Althouse, Sandra K; Nabell, Lisle et al. (2014) A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007. Breast Cancer Res Treat 148:99-106
Chiorean, E Gabriela; Schneider, Bryan P; Akisik, Fatih M et al. (2014) Phase 1 pharmacogenetic and pharmacodynamic study of sorafenib with concurrent radiation therapy and gemcitabine in locally advanced unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 89:284-91
Nudelman, Kelly N H; Wang, Yang; McDonald, Brenna C et al. (2014) Altered cerebral blood flow one month after systemic chemotherapy for breast cancer: a prospective study using pulsed arterial spin labeling MRI perfusion. PLoS One 9:e96713
Hocevar, Barbara A; Kamendulis, Lisa M; Pu, Xinzhu et al. (2014) Contribution of environment and genetics to pancreatic cancer susceptibility. PLoS One 9:e90052
Chitteti, Brahmananda Reddy; Kobayashi, Michihiro; Cheng, Yinghua et al. (2014) CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche. Blood 124:519-29
Chitteti, Brahmananda Reddy; Srour, Edward F (2014) Cell cycle measurement of mouse hematopoietic stem/progenitor cells. Methods Mol Biol 1185:65-78
Chang, Hua-Chen; Lewis, David; Tung, Chun-Yu et al. (2014) Soypeptide lunasin in cytokine immunotherapy for lymphoma. Cancer Immunol Immunother 63:283-95
Speth, Jennifer M; Hoggatt, Jonathan; Singh, Pratibha et al. (2014) Pharmacologic increase in HIF1* enhances hematopoietic stem and progenitor homing and engraftment. Blood 123:203-7

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