Bioinformatics is playing an increasingly important role in cancer research extending from basic evaluation of cancer genetics through translational and clinical research. It is also playing an important role in connecting fields of cancer research that were previously thought to be separate, and to assisting other shared resources in sharing and utilizing large volumes of data. The mission of the HCCC Bioinformatics Shared Resource is to support the informatics needs of the clinical, basic and population scientists of the HCCC. This shared resource has the expertise to collect and utilize large-scale data sets, including molecular assays, is available to all HCCC members. Such uses are rarely a simple matter of deploying an existing software tool by the end user, thus the staff of this shared resource will assist investigators throughout the phases of experiment design and collaborate with the investigator and other shared research resources such as the DNA core and Biostatistics Core in data analysis and interpretation. Bioinformatics Shared Resource staff have the expertise to develop software tools de novo or to adapt existing tools to custom settings.

Public Health Relevance

Bioinformatics is increasingly important in cancer research and is having significant impact on basic, clinical,and population-based research as large amounts of data become available. The Bioinformatics Core also plays a central role in serving the needs of the other shared resources of the HCCC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA086862-12S1
Application #
8533967
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
2016-03-31
Budget Start
2012-05-03
Budget End
2013-03-31
Support Year
12
Fiscal Year
2012
Total Cost
$3,000
Indirect Cost
$1,013
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Garje, Rohan; Chau, Justin J; Chung, Jina et al. (2018) Acute Flare of Bullous Pemphigus With Pembrolizumab Used for Treatment of Metastatic Urothelial Cancer. J Immunother 41:42-44
Ruiz Ciancio, Dario; Vargas, Mauricio R; Thiel, William H et al. (2018) Aptamers as Diagnostic Tools in Cancer. Pharmaceuticals (Basel) 11:
Triplette, Matthew; Crothers, Kristina; Mahale, Parag et al. (2018) Risk of lung cancer in lung transplant recipients in the United States. Am J Transplant :
Andrew, Megan; Kim, Yusung; Ginader, Timothy et al. (2018) Reduction of applicator displacement in MR/CT-guided cervical cancer HDR brachytherapy by the use of patient hover transport system. J Contemp Brachytherapy 10:85-90
Buchakjian, Marisa R; Ginader, Timothy; Tasche, Kendall K et al. (2018) Independent Predictors of Prognosis Based on Oral Cavity Squamous Cell Carcinoma Surgical Margins. Otolaryngol Head Neck Surg 159:675-682
Keck, Kendall J; Breheny, Patrick; Braun, Terry A et al. (2018) Changes in gene expression in small bowel neuroendocrine tumors associated with progression to metastases. Surgery 163:232-239
Schoenfeld, Joshua D; Sibenaller, Zita A; Mapuskar, Kranti A et al. (2018) Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Redox Biol 14:417-422
Kelpsch, Daniel J; Tootle, Tina L (2018) Nuclear Actin: From Discovery to Function. Anat Rec (Hoboken) 301:1999-2013
Gupta, Gaurav; Kuppachi, Sarat; Kalil, Roberto S et al. (2018) Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States. Am J Transplant 18:245-252
Pennington, Steven M; Klutho, Paula R; Xie, Litao et al. (2018) Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Redox Biol 16:401-413

Showing the most recent 10 out of 1080 publications