Small Animal imaging Core (SAIC) The purpose of the Small Animal Imaging Core is to assist HCCC investigators by providing a comprehensive service for non-invasive anatomical and physiological imaging of mice and rats. The ultimate product of the core consists of quantitative image datasets taken longitudinally in scientific studies related to cancer biology, drug development, and assessment of therapeutic intervention. The basic services of the core are 1) Consultative service for imaging modality choice and imaging protocol development, 2) Assistance with ACURF and other regulatory submissions, 3) Animal preparation and monitoring, 4) Single or multiple modality imaging, and 5) Image reconstruction, data analysis, and results interpretation. The small animal specific instrumentation owned and operated directly by the core consists of several imaging modalities including PET, SPECT, gamma camera imaging, autoradiography, and CT. Additionally small animal MRI, ultrasound and optical imaging are available in nearby laboratories. The Core operates a small image processing laboratory including 4 high-end workstations with a suite of multi-modality software available for use, including PMOD, and Inveon Research Workspace, both fully equipped with 3D and pharmacokinetic packages. The core also has its own 12 TB RAID5 networked archive system, mirrored to offsite research networked storage. Consolidation of all high end small animal imaging equipment into a single space under the Small Animal Imaging Core will take place with the completion of the Pappajohn Biomedical Discovery Building (presently under construction - occupancy expected in 2014) where ten dedicated small animal imaging suites, and eight imaging support laboratories will house all SAIC imaging technologies. This strategy is designed to provide efficient, professional, convenient and cost-effective access to imaging equipment and expertise using small animal imaging.

Public Health Relevance

The ability to image cancer non-invasively in small animals is enhancing our ability to periderm basic and applied cancer research. The small animal imaging core supports research geared towards understanding both the behavior of malignancy and the efficacy of new approaches to cancer therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA086862-13
Application #
8466222
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
13
Fiscal Year
2013
Total Cost
$77,723
Indirect Cost
$31,206
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Liu, Q; Kulak, M V; Borcherding, N et al. (2018) A novel HER2 gene body enhancer contributes to HER2 expression. Oncogene 37:687-694
Arthur, Rhonda; Wassertheil-Smoller, Sylvia; Manson, JoAnn E et al. (2018) The Combined Association of Modifiable Risk Factors with Breast Cancer Risk in the Women's Health Initiative. Cancer Prev Res (Phila) 11:317-326
Press, Robert H; Shu, Hui-Kuo G; Shim, Hyunsuk et al. (2018) The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective. Int J Radiat Oncol Biol Phys 102:1219-1235
Viala, Marie; Chiba, Akiko; Thezenas, Simon et al. (2018) Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study. BMC Cancer 18:770
Madsen, Mark T; Menda, Yusuf; O'Dorisio, Thomas M et al. (2018) Technical Note: Single time point dose estimate for exponential clearance. Med Phys 45:2318-2324
Luchtel, Rebecca A; Dasari, Surendra; Oishi, Naoki et al. (2018) Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements. Blood 132:1386-1398
Sabree, Shakoora; Berg, Daniel; Sato, Mariko (2018) Treatment of a pediatric patient with MET-amplified signet ring cell adenocarcinoma of the stomach with crizotinib. Pediatr Blood Cancer 65:e26984
Bharti, Sanjay Kumar; Sommers, Joshua A; Awate, Sanket et al. (2018) A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair. Nucleic Acids Res 46:6238-6256
Reiner, Anne S; Sisti, Julia; John, Esther M et al. (2018) Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study. J Clin Oncol 36:1513-1520
Leelakanok, Nattawut; Geary, Sean; Salem, Aliasger (2018) Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil. J Pharm Sci 107:513-528

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