Small Animal imaging Core (SAIC) The purpose of the Small Animal Imaging Core is to assist HCCC investigators by providing a comprehensive service for non-invasive anatomical and physiological imaging of mice and rats. The ultimate product of the core consists of quantitative image datasets taken longitudinally in scientific studies related to cancer biology, drug development, and assessment of therapeutic intervention. The basic services of the core are 1) Consultative service for imaging modality choice and imaging protocol development, 2) Assistance with ACURF and other regulatory submissions, 3) Animal preparation and monitoring, 4) Single or multiple modality imaging, and 5) Image reconstruction, data analysis, and results interpretation. The small animal specific instrumentation owned and operated directly by the core consists of several imaging modalities including PET, SPECT, gamma camera imaging, autoradiography, and CT. Additionally small animal MRI, ultrasound and optical imaging are available in nearby laboratories. The Core operates a small image processing laboratory including 4 high-end workstations with a suite of multi-modality software available for use, including PMOD, and Inveon Research Workspace, both fully equipped with 3D and pharmacokinetic packages. The core also has its own 12 TB RAID5 networked archive system, mirrored to offsite research networked storage. Consolidation of all high end small animal imaging equipment into a single space under the Small Animal Imaging Core will take place with the completion of the Pappajohn Biomedical Discovery Building (presently under construction - occupancy expected in 2014) where ten dedicated small animal imaging suites, and eight imaging support laboratories will house all SAIC imaging technologies. This strategy is designed to provide efficient, professional, convenient and cost-effective access to imaging equipment and expertise using small animal imaging.

Public Health Relevance

The ability to image cancer non-invasively in small animals is enhancing our ability to periderm basic and applied cancer research. The small animal imaging core supports research geared towards understanding both the behavior of malignancy and the efficacy of new approaches to cancer therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA086862-14
Application #
8640101
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
14
Fiscal Year
2014
Total Cost
$69,760
Indirect Cost
$28,740
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Chrisman, Matthew; Nothwehr, Faryle; Janz, Kathleen et al. (2015) Perceived Resources and Environmental Correlates of Domain-Specific Physical Activity in Rural Midwestern Adults. J Phys Act Health 12:962-7
Chrisman, Matthew; Nothwehr, Faryle; Yang, Ginger et al. (2015) Environmental influences on physical activity in rural Midwestern adults: a qualitative approach. Health Promot Pract 16:142-8
Makkouk, Amani; Weiner, George J (2015) Cancer immunotherapy and breaking immune tolerance: new approaches to an old challenge. Cancer Res 75:10-May
Naderi, Ali (2015) Coagulation factor VII is regulated by androgen receptor in breast cancer. Exp Cell Res 331:239-50
McDowell, Bradley D; Chapman, Cole G; Smith, Brian J et al. (2015) Pancreatectomy predicts improved survival for pancreatic adenocarcinoma: results of an instrumental variable analysis. Ann Surg 261:740-5
Ponto, Laura L Boles; Menda, Yusuf; Magnotta, Vincent A et al. (2015) Frontal hypometabolism in elderly breast cancer survivors determined by [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET): a pilot study. Int J Geriatr Psychiatry 30:587-94
Chrischilles, Elizabeth A; McDowell, Bradley D; Rubenstein, Linda et al. (2015) Survivorship care planning and its influence on long-term patient-reported outcomes among colorectal and lung cancer survivors: the CanCORS disease-free survivor follow-up study. J Cancer Surviv 9:269-78
Makkouk, Amani; Joshi, Vijaya B; Wongrakpanich, Amaraporn et al. (2015) Biodegradable microparticles loaded with doxorubicin and CpG ODN for in situ immunization against cancer. AAPS J 17:184-93
Bhama, A R; Charlton, M E; Schmitt, M B et al. (2015) Factors associated with conversion from laparoscopic to open colectomy using the National Surgical Quality Improvement Program (NSQIP) database. Colorectal Dis 17:257-64
Hoover, Andrew C; Milhem, Mohammed M; Anderson, Carryn M et al. (2015) Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial. Head Neck 37:722-6

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