The Cancer and Developmental Biology Program (CDBP) includes 41 faculty distributed in 14 departments in the Washington University School of Medicine and Danforth campuses. Developmental biologists share the hypothesis that cancer often results from fundamental errors in developmental regulatory mechanisms. CDBP investigators use model organisms to study oncogenes, oncogenic processes, developmental pathways, and to test potential cancer therapies. Over the years, fundamental discoveries in developmental biology have led to the identification of new genes and regulatory mechanisms that are involved in the development of malignancies. Fundamental questions being asked by CDBP faculty include: How do cells in different parts of an embryo come to express very different sets of genes? How are such developmental processes programmed in the genome? What mechanisms regulate maintenance and activation of stem cells? What happens when developmental regulatory mechanisms fail? How do mutations in developmental genes cause cancer? How do developmental regulatory mechanisms prevent cancer? These are a few of the questions that are being answered in detail by the application of the powerful techniques of modern cell and molecular biology to developmental systems. CDBP faculty will continue to use these systems to identify and understand the function of genes that can cause cancer or modulate its outcome. Importantly, several studies within the CDBP have led to pharmacological studies with potential translation to the clinic. CDBP faculty and students meet on a regular basis to discuss research activities. Laboratories studying developmental biology utilize many core facilities within the Siteman Cancer Center. These include the Cancer Center Embryonic Stem Cell Core, Multiplexed Gene Analysis Core, Tissue Procurement Core and High Speed Cell Sorter Core. CDBP members will continue to play a key role in cancer and developmental biology education at Washington University School of Medicine and the Siteman Cancer Center. CDBP is supported by $21,568,623 in funding of which $1,520,881 is in NCI funding and $18,161,968 in other peer reviewed funding. During the current funding period, in the last grant period, members of the CDBP published 640 manuscripts, of which 17.66% represent inter-programmatic and 8.28% resulted from intraprogrammatic collaborations.
A modern view of causes of cancer is that cancer often results from fundamental errors in developmental regulatory mechanisms. CDBP faculty are trying to understand these fundamental regulatory mechanisms in an effort to understand the underiying causes of cancer. These efforts are expected to lead to improved diagnostic, prevention and treatment of cancer.
|Zuiani, Adam; Chen, Kevin; Schwarz, Megan C et al. (2016) A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I. J Virol 90:10499-10512|
|Abboud, Ramzi; Keller, Jesse; Slade, Michael et al. (2016) Severe Cytokine-Release Syndrome after T Cell-Replete Peripheral Blood Haploidentical Donor Transplantation Is Associated with Poor Survival and Anti-IL-6 Therapy Is Safe and Well Tolerated. Biol Blood Marrow Transplant 22:1851-60|
|Johnson, Kimberly J; Zoellner, Nancy L; Gutmann, David H (2016) Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1. Cancer Epidemiol 42:53-9|
|Brownson, Ross C; Dodson, Elizabeth A; Kerner, Jon F et al. (2016) Framing research for state policymakers who place a priority on cancer. Cancer Causes Control 27:1035-41|
|Chou, Chun; Verbaro, Daniel J; Tonc, Elena et al. (2016) The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. Immunity 45:570-82|
|Durai, Vivek; Murphy, Kenneth M (2016) Functions of Murine Dendritic Cells. Immunity 45:719-736|
|Beeman, Scott C; Shui, Ying-Bo; Perez-Torres, Carlos J et al. (2016) O2 -sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models. Magn Reson Med 75:2442-7|
|Mertins, Philipp; Mani, D R; Ruggles, Kelly V et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534:55-62|
|Niu, Haixia; Hadwiger, Gayla; Fujiwara, Hideji et al. (2016) Pathways of retinoid synthesis in mouse macrophages and bone marrow cells. J Leukoc Biol 99:797-810|
|Willet, Spencer G; Mills, Jason C (2016) Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis. Cell Mol Gastroenterol Hepatol 2:546-559|
Showing the most recent 10 out of 947 publications