Eleven years ago, a decision was made to promote tumor immunology research at our institution by including a tumor immunology program as an integral component of a newly forming NCI accredited Comprehensive Cancer Center. This strategy has yielded significant success and today the number of laboratories at Washington University performing tumor immunology related research has risen significantly. More importantly, the last six years have seen an even more significant rise in translational and/or clinical tumor immunology research. Based on the advances in our understanding of immune system-tumor interactions that have occurred over the last 6 years and the research strengths/interests of our program members, the efforts ofthe Tumor Immunology Program are now focused into four thematic areas: (1) the molecular basis of immune recognition of cancer, (2) mechanisms underiying development of host protective, immune effector functions (3) pro-tumorigenic inflammation and immunosuppression and (4) tumor immunotherapy. The long-range goal ofthe Immunology Program is to encourage development of cutting-edge tumor immunology research and facilitate its direct translation into novel diagnostic or immunotherapeutic protocols. Toward these ends, the following four immediate goals will be pursued: (1) continued development of new experimental tumor models using transgenic and gene-targeted mice that more closely recapitulate clinical aspects of human cancer, (2) definition of the structures/antigens of tumors that are the targets of innate and adaptive immune recognition and exploration of mechanisms to enhance the sensitivity/specificity ofthe recognition process, (3) elucidation ofthe roles of innate and adaptive immune response components in either promoting or suppressing anti-tumor immune responses, and (4) explore new avenues to increase the number of inter-departmental and/or collaborative tumor immunology research projects. The program will achieve these goals by continuing to sponsor a number of interactive scientific forums for its members and their research teams and by employing the resources of the Siteman Cancer Center and its cores to encourage the active and interactive participation of both its basic and clinically oriented members. The Tumor Immunology Research Program currently consists of 28 members from 5 departments and 1 school. It has $2,832,508 in NCI funding and $9,939,175 in other peer reviewed support. This is a highly productive program;publishing 451 publications in the last funding period (2004- 2009) of which 11% were intra-programmatic and 2 1% were inter-programmatic.

Public Health Relevance

Before we can use the power and specificity ofthe immune system against cancer we need to learn more about how immunity controls or promotes cancer and how the presence of a tumor affects the function of the immune system. We also need to determine what types of immunotherapy are best suited for particular types of cancer. This program will use the profound immunological and clinical expertise of our members to translate basic discoveries in tumor immunology to more effective cancer diagnostics and/or therapies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Washington University
Saint Louis
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Johnson, Kimberly J; Zoellner, Nancy L; Gutmann, David H (2016) Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1. Cancer Epidemiol 42:53-9
Zuiani, Adam; Chen, Kevin; Schwarz, Megan C et al. (2016) A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I. J Virol 90:10499-10512
Abboud, Ramzi; Keller, Jesse; Slade, Michael et al. (2016) Severe Cytokine-Release Syndrome after T Cell-Replete Peripheral Blood Haploidentical Donor Transplantation Is Associated with Poor Survival and Anti-IL-6 Therapy Is Safe and Well Tolerated. Biol Blood Marrow Transplant 22:1851-60
Durai, Vivek; Murphy, Kenneth M (2016) Functions of Murine Dendritic Cells. Immunity 45:719-736
Brownson, Ross C; Dodson, Elizabeth A; Kerner, Jon F et al. (2016) Framing research for state policymakers who place a priority on cancer. Cancer Causes Control 27:1035-41
Chou, Chun; Verbaro, Daniel J; Tonc, Elena et al. (2016) The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. Immunity 45:570-82
Niu, Haixia; Hadwiger, Gayla; Fujiwara, Hideji et al. (2016) Pathways of retinoid synthesis in mouse macrophages and bone marrow cells. J Leukoc Biol 99:797-810
Beeman, Scott C; Shui, Ying-Bo; Perez-Torres, Carlos J et al. (2016) O2 -sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models. Magn Reson Med 75:2442-7
Mertins, Philipp; Mani, D R; Ruggles, Kelly V et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534:55-62
Murphy, Theresa L; Grajales-Reyes, Gary E; Wu, Xiaodi et al. (2016) Transcriptional Control of Dendritic Cell Development. Annu Rev Immunol 34:93-119

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