Located in the heart of the University's medical complex, the Small Animal Cancer Imaging Core provides intellectual and physical resources devoted to magnetic resonance imaging (MRI), positron emission tomography, (PET), and optical tomography (OT) directed toward small laboratory animals such as hamsters, rats and mice. MRI resources include a high-field 11.7 tesla multinuclear scanner, one of only a few worldwide, and three 4.7 tesia multinuclear scanners. Recent upgrades of electronics consoles, gradient coils, and gradient power supplies, have restored these instruments to state-of-the-art quality. The PET/CT Component is centered on two microPET scanners from Siemens Medical, including a newly acquired, state-of-the-art Inveon microPET-CT instrument. Two cyclotrons and an associated radiochemistry laboratory are connected to the PET facility via a pneumatic tube system and a small-bore gas line for transport of liquid (contained in syringes) and gaseous radiopharmaceuticals. Both MRI and PET scanners offer sensitivity and resolution optimized for small-animal research. Additional resources for support of small-animal imaging include housing, physiologic support and monitoring equipment, surgical procedure rooms, wet chemistry laboratories, and data analysis and archival systems. The Core provides Siteman Cancer Center members with the latest in small-animal MRI, PET, and OT capabilities. Highly skilled staff members are available to assist, advise, and collaborate on projects of interest to Siteman members. For the last five years, the Small Animal Cancer Imaging Core has been supported primarily through the National Cancer Institute (NCI) Small Animal Imaging Resource Program (SAIRP). Washington University Small Animal Imaging Resource (WUSAIR) was one of the original five SAIRP centers, established in 1999, and received ~$3 million in total support from 2004 to 2009.
MRI and PET are widely employed in the clinic;thus, new MR and PET imaging technology developed in the Small Animal Imaging Core can be seamlessly and immediately translated to the clinic for the direct benefit of cancer patients. In addition, the Core provides imaging platforms for pre-clinical development and assessment of new therapies for cancer treatment.
|Engle, E K; Fisher, D A C; Miller, C A et al. (2015) Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia 29:869-76|
|Zihni, Ahmed M; Cavallo, Jaime A; Thompson Jr, Dominic M et al. (2015) Evaluation of absorbable mesh fixation devices at various deployment angles. Surg Endosc 29:1605-13|
|Rosenbaum, Joan L; Smith, Joan R; Yan, Yan et al. (2015) Impact of a Neonatal-Bereavement-Support DVD on Parental Grief: A Randomized Controlled Trial. Death Stud 39:191-200|
|Solga, Anne C; Pong, Winnie W; Walker, Jason et al. (2015) RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia 63:531-48|
|Lewis Jr, James S; Ali, Sahirzeeshan; Luo, Jingqin et al. (2014) A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol 38:128-37|
|Yamada, Tomoko; Yang, Yue; Hemberg, Martin et al. (2014) Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron 83:122-34|
|Jorns, Julie M; Thomas, Dafydd G; Healy, Patrick N et al. (2014) Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med 138:1507-13|
|Griffey, Richard T; Jeffe, Donna B; Bailey, Thomas (2014) Emergency physicians' attitudes and preferences regarding computed tomography, radiation exposure, and imaging decision support. Acad Emerg Med 21:768-77|
|Tait, Sarah; Pacheco, Jose M; Gao, Feng et al. (2014) Body mass index, diabetes, and triple-negative breast cancer prognosis. Breast Cancer Res Treat 146:189-97|
|Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D et al. (2014) Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study. Acad Med 89:84-93|
Showing the most recent 10 out of 514 publications