The primary goal of the Protocol Review and Monitoring Committee (PRMC) is to ensure that all cancerrelated clinical research studies involving human subjects that are conducted within Washington University Medical Center are scientifically evaluated and prioritized by the Siteman Cancer Center (SCC), Studies that do not have prior NCI review (institutional and industry-initiated studies) are reviewed by the full PRMC to ensure that they are (1) scientifically and statistically sound, (2) appropriately designed, (3) feasible for completion, (4) prioritized by the appropriate research working group(s), and (5) in compliance with NIH guidelines for clinical trials, including monitoring for accrual and undue toxicity (if applicable). Studies that have received prior NCI review (primarily cooperative group studies) are reviewed administratively (by PRMC Co-Chairs) to ensure that they have been prioritized by the appropriate research working group(s), and that all SCC guidelines have been addressed, as appropriate. For the purposes of this committee, a cancer research study is defined as a formal research plan that: (1) is intended to evaluate an untested, unproven or unknown regimen or procedure for the screening, diagnosis, staging, treatment, support, outcome, prevention, control, or characterization of human subjects in regard to cancer, or compares standard to unproven regimens or procedures, and (2) requires the approval ofthe Institutional Review Board (IRB). The PRMC is responsible for: Providing scientific peer-review for all investigator- and industry-initiated cancer research studies. Reviewing all active cancer research studies for renewal/termination (the Quality Assurance and Safety Monitoring Committee can independently close studies but report findings to the PRMC). Ensuring that all competing studies have been prioritized by the leadership ofthe appropriate research working group(s). Monitoring accrual in all active cancer research studies. Tracking and reporting information about study design and execution.

Public Health Relevance

The Protocol Review and Monitoring Committee (PRMC) ensures that all cancer-related clinical research studies involving human subjects that are conducted within Washington University Medical Center are scientifically evaluated and prioritized by the Siteman Cancer Center (SCC)

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Engle, E K; Fisher, D A C; Miller, C A et al. (2015) Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia 29:869-76
Zihni, Ahmed M; Cavallo, Jaime A; Thompson Jr, Dominic M et al. (2015) Evaluation of absorbable mesh fixation devices at various deployment angles. Surg Endosc 29:1605-13
Rosenbaum, Joan L; Smith, Joan R; Yan, Yan et al. (2015) Impact of a Neonatal-Bereavement-Support DVD on Parental Grief: A Randomized Controlled Trial. Death Stud 39:191-200
Solga, Anne C; Pong, Winnie W; Walker, Jason et al. (2015) RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia 63:531-48
Yamada, Tomoko; Yang, Yue; Hemberg, Martin et al. (2014) Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron 83:122-34
Lewis Jr, James S; Ali, Sahirzeeshan; Luo, Jingqin et al. (2014) A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol 38:128-37
Griffey, Richard T; Jeffe, Donna B; Bailey, Thomas (2014) Emergency physicians' attitudes and preferences regarding computed tomography, radiation exposure, and imaging decision support. Acad Emerg Med 21:768-77
Jorns, Julie M; Thomas, Dafydd G; Healy, Patrick N et al. (2014) Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med 138:1507-13
Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D et al. (2014) Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study. Acad Med 89:84-93
Tait, Sarah; Pacheco, Jose M; Gao, Feng et al. (2014) Body mass index, diabetes, and triple-negative breast cancer prognosis. Breast Cancer Res Treat 146:189-97

Showing the most recent 10 out of 514 publications