The Siteman Cancer Center (SCC) developmental funds support a successful seed grant program and will jointly support two developing shared resources, the High-Throughput Screening (HTS) Core and the Dissemination & Implementation (D&l) Core. The SCC Research Development Awards (RDA) are offered annually to SCC members to support and encourage translational, cancer-related projects. In order to promote inter-programmatic research sciences, co-investigators must be from different research areas (Basic Sciences, Translational and Clinical Research, Prevention and Control, and Oncologic Imaging). The program has been highly successful at providing new collaborations between investigators and has given investigators the opportunity to generate preliminary data that has then been used to apply and obtain external, peer-reviewed funding. The High-Throughput Core represents a multi-departmental effort with fiscal support for establishing the Core coming from the Siteman Cancer Center;the Washington University School of Medicine;the Departments of Radiology, Developmental Biology, and Cell Biology;the NCI PSO Molecular Imaging Center, and the Howard Hughes Medical Institute. Overall, nearly $2 million has been invested in the establishment of this resource to date. This Core serves as an outstanding on-going example of how the SCC and a P50 program have leveraged university resources and continue to stimulate interdisciplinary activity throughout the WU campus. This core enables small molecule screens to identify agonists/antagonist of biologically/pathologically interesting proteins and perform sub- or genome-wide siRNA screens in live cell functional assays. The Dissemination &Implementation (D&l) Core will accelerate the public health impact of SCC work through research. This core leverages resources available across Washington University, including those ofthe Institute of Clinical and Translational Sciences (ICTS, the institutional CTSA), the Centerfor Excellence in Cancer Communication (CECCR) (NCI funded), and the Prevention Research Center in St. Louis (CDC funded). Goals are to increase the quantity, quality, and sustainability of D&l research, to identify specific approaches and tools to enhance the dissemination of SCC discoveries, and to apply effective strategies to disseminate evidencebased discoveries from SCC into clinical and public health practice.

Public Health Relevance

The Siteman Cancer Center will utilize developmental funds to support its ongoing successful research development awards along with two newly developed shared resources, both which will support and enable researchers to continue generating high quality and novel cancer research.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Engle, E K; Fisher, D A C; Miller, C A et al. (2015) Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia 29:869-76
Zihni, Ahmed M; Cavallo, Jaime A; Thompson Jr, Dominic M et al. (2015) Evaluation of absorbable mesh fixation devices at various deployment angles. Surg Endosc 29:1605-13
Rosenbaum, Joan L; Smith, Joan R; Yan, Yan et al. (2015) Impact of a Neonatal-Bereavement-Support DVD on Parental Grief: A Randomized Controlled Trial. Death Stud 39:191-200
Solga, Anne C; Pong, Winnie W; Walker, Jason et al. (2015) RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia 63:531-48
Yamada, Tomoko; Yang, Yue; Hemberg, Martin et al. (2014) Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron 83:122-34
Lewis Jr, James S; Ali, Sahirzeeshan; Luo, Jingqin et al. (2014) A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol 38:128-37
Griffey, Richard T; Jeffe, Donna B; Bailey, Thomas (2014) Emergency physicians' attitudes and preferences regarding computed tomography, radiation exposure, and imaging decision support. Acad Emerg Med 21:768-77
Jorns, Julie M; Thomas, Dafydd G; Healy, Patrick N et al. (2014) Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med 138:1507-13
Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D et al. (2014) Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study. Acad Med 89:84-93
Tait, Sarah; Pacheco, Jose M; Gao, Feng et al. (2014) Body mass index, diabetes, and triple-negative breast cancer prognosis. Breast Cancer Res Treat 146:189-97

Showing the most recent 10 out of 514 publications