The Biostatistics and Biolnformatics Shared Resource (BBSR) provides biostatistical and bioinformatics leadership and support for research within the Cancer Center. The BBSR plays a critical role in the design and analysis of cancer related investigations, including clinical trials, epidemiological studies, and laboratory-based studies. The BBSR provides a full range of biostatistical services, including study design, sample size calculations, data analysis and interpretation, protocol reviews, and development of novel statistical methodologies. The BBSR also provides support for cancer researchers to store, access, and analyze large-scale genomic, proteomic, clinical, image-based, and systems biology datasets.The overall goals of the Resource are to provide: (1) biostatistical and bioinformatics support to Cancer Center researchers through service and collaborative activities;(2) training in the use of statistical software and biostatistical methods, through regular short courses and one-on-one sessions, and technical guidance and technology background to Cancer Center members and associated scientists seeking to use parallel supercomputing and database hardware and software in cancer-based biomedical research;(3) development of novel biostatistical and bioinformatic methods to enhance Cancer Center research projects; and (4) dissemination of capabilities, by continuing with the development of our website that identifies personnel and services provided to allow wider knowledge of the biostatistical and bioinformatics support available to Cancer Center investigators. Edward J. Bedrick, Ph.D. is Director of the Resource. Susan R. Atlas, Ph.D, and Christine Stidley, Ph.D. are Co-Directors of the Resource for bioinformatics and biostatistics, resectively. Dr. Bedrick has >20 years experience in biostatistics. Dr. Atlas has >20 years experience in scientific computing and bioinformatics. Dr. Stidley supports the large lung cancer research and SEER efforts. The Resource includes eight faculty and scientific staff, with a broad range of areas of expertise. Since 2005, Cancer Center members published more than 40 articles in collaboration with Resource faculty and staff. Resource members are co-investigators on 11 peer-reviewed extra-mural grants with Cancer Center members with several pending. More than 30 Cancer Center members representing all 4 Research Programs are making extensive use ofthe Resource.
The Resource enhances the clinical trials and Research Programs of the Cancer Center by providing critical expertise in the design and analysis of cancer related studies. These research efforts would be not Just hampered, but often rendered meaningless, without appropriate biostatistical and bioinformatics support. The Resource also provides statistical support during the development of projects that will ultimately lead to both increased research funding to the Cancer Center and support for members of the Resource. Furthermore, the Bioinformatics technical staff members provide the mechanisms by which large-scale datasets and associated clinical covariate data generated by Cancer Center researchers are reliably managed, stored, annotated, archived, and disseminated. These activifies are critical to meeting the Specific Aims of Cancer Center research grants that are based on the generation and analysis of large-scale genomic datasets for large patient cohorts and emerging large-scale deep sequencing data.
|Flook, Adam M; Yang, Jianquan; Miao, Yubin (2014) Substitution of the Lys linker with the ?-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated ?-melanocyte stimulating hormone peptides. J Med Chem 57:9010-8|
|Davies, Suzy; Holmes, Anna; Lomo, Lesley et al. (2014) High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Int J Gynecol Pathol 33:402-10|
|Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan et al. (2014) Real-time detection of protein trafficking with high-throughput flow cytometry (HTFC) and fluorogen-activating protein (FAP) base biosensor. Curr Protoc Cytom 67:Unit 9.43.|
|Morris, K T; Khan, H; Ahmad, A et al. (2014) G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. Br J Cancer 110:1211-20|
|Vaughan, Roger A; Gannon, Nicholas P; Garcia-Smith, Randi et al. (2014) ?-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer 13:14|
|Lu, Jie; Hathaway, Helen J; Royce, Melanie E et al. (2014) Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett 24:725-30|
|Campen, Matthew J; Paffett, Michael L; Colombo, E Sage et al. (2014) Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling. PLoS One 9:e97084|
|Yang, Jianquan; Flook, Adam M; Feng, Changjian et al. (2014) Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorg Med Chem Lett 24:195-8|
|Hill, Jeff W; Thompson, Jeffrey F; Carter, Mark B et al. (2014) Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One 9:e96761|
|Scaling, Allison L; Prossnitz, Eric R; Hathaway, Helen J (2014) GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast. Horm Cancer 5:146-60|
Showing the most recent 10 out of 123 publications