The Keck-UNM small animal models and imaging resource provides value to members of the UNM Cancer Center by providing a comprehensive service in the development and use of animal models for basic and pre-clinical cancer research. It was established in July 2006 as a developing resource with both internal CC funds and a contribution from the developmental funds from the UNM P30 award. The resource offers a wide range of services, including consultation, protocol development and guidance through the compliance process, animal housing (provided through the Animal Resource Facility, husbandry, handling, treatment, monitoring, surgery, and dissection/ necropsy. In addition, the resource has state-of-the-art capabilities in small animal radioimaging through the Keck-UNM Small Animal Imaging Resource, (made possible by a grant from the Keck Foundation. MRI and other magnetic-based imaging modalities are also available, and many investigators are actively involved in imaging technology research and development. The Resource is supervised by two faculty Co-Directors, Helen Hathaway and Jeffrey Norenberg, and day-to-day services are provided by experienced technical staff. The Animal Resource Facility supports the KUAMIR and all animal research at UNM HSC by providing outstanding animal care. The small animal models component of the resource specializes in xenograft and genetically modified models of cancer, and is continually developing and offering new techniques to enhance researchers'cancer research programs. The small animal imaging component of the resource is involved in emerging radioimaging and therapeutic research, and offers users a broad range of radiolabeling and in vivo analysis. In the reporting period, 17 Cancer Center members representing all 4 research programs and funded by 18 NIH, NSF, ACS, or DOD research grants used Resource services. In the first two years, users were not charged for use in order to attract new users. In the last year, we have begun to apply charges to new users in order to recoup a portion of our operating expenses.
The Keck-UNM Animal Models and Imaging Resource provides Cancer Center researchers with comprehensive services for in vivo cancer research that can enhance and extend their research programs. The establishment of this resource has also stimulated efforts in acquiring new tools and capabilities in basic and pre-clinical research, which will enrich the goals of the Cancer Center.
|Flook, Adam M; Yang, Jianquan; Miao, Yubin (2014) Substitution of the Lys linker with the ?-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated ?-melanocyte stimulating hormone peptides. J Med Chem 57:9010-8|
|Davies, Suzy; Holmes, Anna; Lomo, Lesley et al. (2014) High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Int J Gynecol Pathol 33:402-10|
|Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan et al. (2014) Real-time detection of protein trafficking with high-throughput flow cytometry (HTFC) and fluorogen-activating protein (FAP) base biosensor. Curr Protoc Cytom 67:Unit 9.43.|
|Morris, K T; Khan, H; Ahmad, A et al. (2014) G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. Br J Cancer 110:1211-20|
|Vaughan, Roger A; Gannon, Nicholas P; Garcia-Smith, Randi et al. (2014) ?-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer 13:14|
|Lu, Jie; Hathaway, Helen J; Royce, Melanie E et al. (2014) Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett 24:725-30|
|Campen, Matthew J; Paffett, Michael L; Colombo, E Sage et al. (2014) Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling. PLoS One 9:e97084|
|Yang, Jianquan; Flook, Adam M; Feng, Changjian et al. (2014) Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorg Med Chem Lett 24:195-8|
|Hill, Jeff W; Thompson, Jeffrey F; Carter, Mark B et al. (2014) Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One 9:e96761|
|Scaling, Allison L; Prossnitz, Eric R; Hathaway, Helen J (2014) GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast. Horm Cancer 5:146-60|
Showing the most recent 10 out of 123 publications