The Keck-UNM Genomics Resource (KUGR) is a full service shared resource focusing on gene expression, genomics and microarray technologies and located on the first fioor of the Cancer Research Facility. The resource is supervised by faculty Director Scott Ness, Ph.D. and Co-Director Jeremy Edwards, Ph.D., and is operated by an experienced, full fime staff. It was established in late 1999 with institutional funds, expanded a year later with a grant from the W.M. Keck Foundation and is currently supported by user fees. State of New Mexico Tobacco Settlement Funds and Cancer Center funding. The resource focuses on gene expression and genotyping assays using Affymetrix and quantitafive real fime PCR assays and provides full sample to data analysis service including help with experimental design, microarray data analysis and the preparafion of publication-quality figures. The resource also provides access to several specialized shared instruments. The resource personnel analyze complex data sets using sophisficated statistical tools and software packages and adhere to strict quality control guidelines, producing data that are MIAME compliant. Interactions with the Biostatistics/Bioinformatics (9.1.4) cores allows the resource to offer a complete range of services from detailed experimental design through advanced data analysis. Cancer Center members receive a 20% co-pay benefit that reduces their cost for KUGR resource services. Since 2001, the resource has analyzed an average of more than 500 Affymetrix GeneChips per year. In FY 2009, the resource was used by 16 Cancer Center members from all four research programs and supported 23 acfive grants. During that reporting year, 79% of the KUGR resource services were billed to Cancer Center members. During FY 2010, the resource began offering a suite of new services based on next-generafion DNA sequencing technologies, including epigenetics/chromatin immunoprecipitation (ChlP-seq) assays, transeriptome/RNA sequencing and whole genome sequencing. The development of these and related nextgenerafion technologies form the basis of a new Innovafion and Discovery Core, which includes a substanfial new investment by the CC in computational resources and personnel.

Public Health Relevance

Cancer is a genetic disease: cancer cells accumulate mutations that alter the activities or expression of important regulatory proteins. The genomics shared resource provides UNM researchers with specialized technologies for measuring changes in gene expression and detecfing genetic changes in tumor samples and in patients with different risks of acquiring cancer. These experiments will lead to a better understanding of cancer mechanisms, and the development of new diagnostic and therapeutic strategies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Flook, Adam M; Yang, Jianquan; Miao, Yubin (2014) Substitution of the Lys linker with the ?-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated ?-melanocyte stimulating hormone peptides. J Med Chem 57:9010-8
Davies, Suzy; Holmes, Anna; Lomo, Lesley et al. (2014) High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Int J Gynecol Pathol 33:402-10
Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan et al. (2014) Real-time detection of protein trafficking with high-throughput flow cytometry (HTFC) and fluorogen-activating protein (FAP) base biosensor. Curr Protoc Cytom 67:Unit 9.43.
Morris, K T; Khan, H; Ahmad, A et al. (2014) G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. Br J Cancer 110:1211-20
Vaughan, Roger A; Gannon, Nicholas P; Garcia-Smith, Randi et al. (2014) ?-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer 13:14
Lu, Jie; Hathaway, Helen J; Royce, Melanie E et al. (2014) Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett 24:725-30
Campen, Matthew J; Paffett, Michael L; Colombo, E Sage et al. (2014) Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling. PLoS One 9:e97084
Yang, Jianquan; Flook, Adam M; Feng, Changjian et al. (2014) Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorg Med Chem Lett 24:195-8
Hill, Jeff W; Thompson, Jeffrey F; Carter, Mark B et al. (2014) Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One 9:e96761
Scaling, Allison L; Prossnitz, Eric R; Hathaway, Helen J (2014) GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast. Horm Cancer 5:146-60

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