The Keck-UNM small animal models and imaging resource provides value to members of the UNM Cancer Center by providing a comprehensive service in the development and use of animal models for basic and pre-clinical cancer research. It was established in July 2006 as a developing resource with both internal CC funds and a contribution from the developmental funds from the UNM P30 award. The resource offers a wide range of services, including consultation, protocol development and guidance through the compliance process, animal housing (provided through the Animal Resource Facility, husbandry, handling, treatment, monitoring, surgery, and dissection/ necropsy. In addition, the resource has state-of-the-art capabilities in small animal radioimaging through the Keck-UNM Small Animal Imaging Resource, (made possible by a grant from the Keck Foundation. MRI and other magnetic-based imaging modalities are also available, and many investigators are actively involved in imaging technology research and development. The Resource is supervised by two faculty Co-Directors, Helen Hathaway and Jeffrey Norenberg, and day-to-day services are provided by experienced technical staff. The Animal Resource Facility supports the KUAMIR and all animal research at UNM HSC by providing outstanding animal care. The small animal models component of the resource specializes in xenograft and genetically modified models of cancer, and is continually developing and offering new techniques to enhance researchers'cancer research programs. The small animal imaging component of the resource is involved in emerging radioimaging and therapeutic research, and offers users a broad range of radiolabeling and in vivo analysis. In the reporting period, 17 Cancer Center members representing all 4 research programs and funded by 18 NIH, NSF, ACS, or DOD research grants used Resource services. In the first two years, users were not charged for use in order to attract new users. In the last year, we have begun to apply charges to new users in order to recoup a portion of our operating expenses.
The Keck-UNM Animal Models and Imaging Resource provides Cancer Center researchers with comprehensive services for in vivo cancer research that can enhance and extend their research programs. The establishment of this resource has also stimulated efforts in acquiring new tools and capabilities in basic and pre-clinical research, which will enrich the goals of the Cancer Center.
|Kuehl, Philip J; Grimes, Marcie J; Dubose, Devon et al. (2018) Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model. Drug Deliv 25:1127-1136|
|Köbel, Martin; Luo, Li; Grevers, Xin et al. (2018) Ovarian Carcinoma Histotype: Strengths and Limitations of Integrating Morphology With Immunohistochemical Predictions. Int J Gynecol Pathol :|
|Bredemeyer, Andrea L; Edwards, Bruce S; Haynes, Mark K et al. (2018) High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining. SLAS Discov 23:624-633|
|Orlow, Irene; Shi, Yang; Kanetsky, Peter A et al. (2018) The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival. Pigment Cell Melanoma Res 31:287-296|
|Sharma, Geetanjali; Mauvais-Jarvis, Franck; Prossnitz, Eric R (2018) Roles of G protein-coupled estrogen receptor GPER in metabolic regulation. J Steroid Biochem Mol Biol 176:31-37|
|Perez, Dominique R; Edwards, Bruce S; Sklar, Larry A et al. (2018) High-Throughput Flow Cytometry Drug Combination Discovery with Novel Synergy Analysis Software, SynScreen. SLAS Discov 23:751-760|
|Deretic, Vojo; Prossnitz, Eric; Burge, Mark et al. (2018) Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy 14:925-929|
|Hill, Deirdre A; Friend, Sarah; Lomo, Lesley et al. (2018) Breast cancer survival, survival disparities, and guideline-based treatment. Breast Cancer Res Treat 170:405-414|
|Guo, Yan; Yu, Hui; Wang, Jing et al. (2018) The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer. Genes (Basel) 9:|
|Hatch, Ellen W; Geeze, Mary Beth; Martin, Cheyenne et al. (2018) Variability of PD-L1 expression in mastocytosis. Blood Adv 2:189-199|
Showing the most recent 10 out of 344 publications