The Program in Radiation Biology is focused on ways in which the effectiveness of radiotherapy can increase local tumor control and survival of cancer patients. Three different approaches are being pursued to achieve this goal: 1) Develop pharmacologic and biologic agents to combine with radiotherapy and chemotherapy to improve local tumor control and prevent metastatic spread; 2) Design new approaches to administer radiotherapy or combined modality therapy to test in clinical trials;3) Identify genetic determinants using yeast and mammalian genetics that influence the response of tumors to radiation or the combination of chemotherapy and radiation. The research of program members has resulted in a series of important findings that include the identification of Prl-3 (phosphatase of regenerating liver-3) as a p53 target gene, the identification of the molecular pathways that give rise to intercellular polarity, developing new hypoxic-specific cytotoxins for cancer therapy, identifying new genes that are essential for adaptation to stress that are essential for metastasis, elucidating the signaling pathways that integrate DNA damage recognition, checkpoint signaling and DNA repair, generation of mouse models to study in vivo stress responses and targeted therapy, expanding the use of hypofractionated radiosurgery to treat solid tumors, developing new approaches to generate protons for therapeutic use and developing molecular and functional imaging techniques to direct the delivery of radiotherapy. The 26 program members representing the School of Medicine and the School of Humanities and Sciences are supported by peer-reviewed research and training grants totaling $6,826,435, including 16 R01s, 2P01s, 2 T32s. The members of this program are highly motivated and interactive in their goal to take fundamental discoveries in the laboratory and develop them to increase the efficacy of radiotherapy to control tumor growth and metastasis.

Public Health Relevance

The overall objective of the program is to translate new findings from the laboratory to the clinic to improve radiotherapy treatment effectiveness in cancer patients and to reduce late-treatment-related toxicities.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Stanford University
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Denny, Sarah K; Yang, Dian; Chuang, Chen-Hua et al. (2016) Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility. Cell 166:328-42
Li, Jian; Pfeffer, Suzanne R (2016) Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export. Elife 5:
Chuang, Jody C; Shrager, Joseph B; Wakelee, Heather A et al. (2016) Concordant and Discordant EGFR Mutations in Patients With Multifocal Adenocarcinomas: Implications for EGFR-Targeted Therapy. Clin Ther 38:1567-76
Wanigatunga, Amal A; Sourdet, Sandrine S; LaMonte, Michael J et al. (2016) Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative. Public Health Nutr 19:3169-3177
Zanganeh, Saeid; Hutter, Gregor; Spitler, Ryan et al. (2016) Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat Nanotechnol 11:986-994
Hiniker, Susan M; Reddy, Sunil A; Maecker, Holden T et al. (2016) A Prospective Clinical Trial Combining Radiation Therapy With Systemic Immunotherapy in Metastatic Melanoma. Int J Radiat Oncol Biol Phys 96:578-88
Grüner, Barbara M; Schulze, Christopher J; Yang, Dian et al. (2016) An in vivo multiplexed small-molecule screening platform. Nat Methods 13:883-9
Chen, Frank W; Sundaram, Vandana; Chew, Thomas A et al. (2016) Advanced Stage Colorectal Cancer in Persons Younger Than 50 Years not Associated With Longer Duration of Symptoms or Time to Diagnosis. Clin Gastroenterol Hepatol :
Zhu, Gefei Alex; Lira, Ruth; Colevas, Alexander Dimitrios (2016) Discordance in routine second opinion pathology review of head and neck oncology specimens: A single-center five year retrospective review. Oral Oncol 53:36-41
Brady, Jennifer J; Chuang, Chen-Hua; Greenside, Peyton G et al. (2016) An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency. Cancer Cell 29:697-710

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