The Biostatistics Resource is a new resource that arose from existing successful programs in theBiostatistics, Informatics, and Data Management Section of the Breast Center, and in the BioinformaticsResource of the Prostate SPORE. This BCMCC Resource currently comprises three PhD faculty, one MSfaculty, and three MS staff biostatisticians. The Resource is already well-integrated into the Cancer Center,providing support to investigators in every Program during the last year and coauthoring 22 peer-reviewedpublications with Cancer Center investigators. More than 70% of the current personnel budget for theResource was covered by charge-backs on peer-reviewed funding.The Biostatistics Resource is led by Susan G. Hilsenbeck, Ph.D., who has extensive experience inorganizing and providing biostatistical and data management support for both cancer clinical trials and basicresearch studies. The primary purpose of the Resource is to support the research efforts of the CancerCenter through collaboration on biostatistical aspects of design, conduct, analysis, and interpretation ofclinical and basic science studies. This will be accomplished by providing biostatistical assistanceincluding general consultation, experimental design, assistance with conduct of clinical trials, statisticalanalysis, methodologic development, and interpretation; education and training; statistical review forPRMS; and consultation on database development. In order to truly fulfill this purpose, the Resource willhave to expand. We will first recruit additional faculty with expertise in clinical trials in order to meet thepressing and immediate need in this area. Subsequent recruits will address unmet needs in more basic andgenomic studies. We are also reaching out to other quantitative scientists within the College who havespecial expertise that may benefit Cancer Center investigators. In this way the Resource will provide CancerCenter investigators with strong, broad-based biostatistical expertise.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
1P30CA125123-01
Application #
7514692
Study Section
Subcommittee G - Education (NCI)
Project Start
2007-07-01
Project End
2010-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
1
Fiscal Year
2007
Total Cost
$163,526
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Creighton, Chad J (2018) The clinical applications of The Cancer Genome Atlas project for bladder cancer. Expert Rev Anticancer Ther 18:973-980
Guarducci, Cristina; Bonechi, Martina; Benelli, Matteo et al. (2018) Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer. NPJ Breast Cancer 4:38
Byrd, Tiara T; Fousek, Kristen; Pignata, Antonella et al. (2018) TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res 78:489-500
Xing, Zhen; Zhang, Yanyan; Liang, Ke et al. (2018) Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res 78:4524-4532
Chiang, Angie C A; Fowler, Stephanie W; Savjani, Ricky R et al. (2018) Combination anti-A? treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med 215:1349-1364
Szwarc, Maria M; Hai, Lan; Gibbons, William E et al. (2018) Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics Reproduction 156:387-395
Nguyen, Tuan M; Kabotyanski, Elena B; Dou, Yongchao et al. (2018) FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation. Cancer Res 78:4229-4240
Kho, Jordan; Tian, Xiaoyu; Wong, Wing-Tak et al. (2018) Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet 103:276-287
Liu, Yanhong; O'Brien, Jacqueline L; Ajami, Nadim J et al. (2018) Lung tissue microbial profile in lung cancer is distinct from emphysema. Am J Cancer Res 8:1775-1787
Scavuzzo, Marissa A; Hill, Matthew C; Chmielowiec, Jolanta et al. (2018) Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Nat Commun 9:3356

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