The Viral and Molecular Oncogenesis (VMO) Research Program consists of investigators who are conducting fundamental research on the molecular basis of cancer development. The program has three thematic areas: (1) Chromosomes and mitotic regulation, (2) Oncogenic signaling, and (3) Viral oncogenesis. The program consists of 36 primary members from 10 academic departments;27 of 28 (96%) of the research members are funded. Peer-reviewed grant funds total nearly $16.0 million annually, with $3.8 million from the National Cancer Institute. Twenty-nine secondary members also participate in the VMO Program. Since its initial review, the program has built on its strengths and improved in areas of weakness. The program was reorganized around themes that better reflect member strengths, encouraged new collaborations by targeted use of pilot grant funds, and organized joint retreats. Members of the program published 187 cancer-related manuscripts in peer-reviewed journals;of these 20% represented intraprogrammatic collaborations (an increase from 3%) and 31% were interprogrammatic. Translational research efforts saw a novel Stat3 inhibitor moving toward clinical trial. A new initiative in the area of HIV-associated malignancies has been undertaken;it draws on our strengths in virology, addresses an emerging area of need, has translational opportunities, and involves a collaboration between the Cancer Center and the Center for AIDS Research. The program leaders are Janet S. Butel, Ph.D. and William R. Brinkley, Ph.D.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
United States
Zip Code
Addison, Joseph B; Koontz, Colton; Fugett, James H et al. (2015) KAP1 promotes proliferation and metastatic progression of breast cancer cells. Cancer Res 75:344-55
Torbit, Lindsey A; Albiani, Jenna J; Crangle, Cassandra J et al. (2015) Fear of recurrence: the importance of self-efficacy and satisfaction with care in gay men with prostate cancer. Psychooncology 24:691-8
Bhattacharya, Abhisek; Parillon, Xyanthine; Zeng, Shenyan et al. (2014) Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis. J Biol Chem 289:26525-32
Ramasamy, Ranjith; Ridgeway, Alex; Lipshultz, Larry I et al. (2014) Integrative DNA methylation and gene expression analysis identifies discoidin domain receptor 1 association with idiopathic nonobstructive azoospermia. Fertil Steril 102:968-973.e3
Kowalkowski, Marc A; Day, Rena S; Du, Xianglin L et al. (2014) Cumulative HIV viremia and non-AIDS-defining malignancies among a sample of HIV-infected male veterans. J Acquir Immune Defic Syndr 67:204-11
Thrift, Aaron P; Garcia, Jose M; El-Serag, Hashem B (2014) A multibiomarker risk score helps predict risk for Barrett's esophagus. Clin Gastroenterol Hepatol 12:1267-71
Young, Evelin; Zheng, Ze-Yi; Wilkins, Angela D et al. (2014) Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Mol Cell Biol 34:374-85
Anurathapan, Usanarat; Leen, Ann M; Brenner, Malcolm K et al. (2014) Engineered T cells for cancer treatment. Cytotherapy 16:713-33
Thrift, Aaron P; Kramer, Jennifer R; Alsarraj, Abeer et al. (2014) Fat mass by bioelectrical impedance analysis is not associated with increased risk of Barrett esophagus. J Clin Gastroenterol 48:218-23
Geldres, Claudia; Savoldo, Barbara; Hoyos, Valentina et al. (2014) T lymphocytes redirected against the chondroitin sulfate proteoglycan-4 control the growth of multiple solid tumors both in vitro and in vivo. Clin Cancer Res 20:962-71

Showing the most recent 10 out of 272 publications