Recent data indicate dramatic increases in both awareness and use of electronic cigarettes (e-cigarettes) in the USA. Moreover, e-cigarette use is higher among current smokers than former- or never-smokers. This is of considerable public health significance since very little is known about the effects that e-cigarettes have on brain functioning, behavior, and physiology. This P30 application includes two key projects: project 1 will consist of two laboratory-based experiments and project 2 will be a community-based experiment. For the laboratory-based experiments, non-treatment seeking cigarette smokers (N=90/group) will be evaluated after exposure to e-cigarettes (0 or 18 mg) or their own cigarette on three separate visits: This will allow us to directly compare and evaluate e-cigarettes against smokers'preferred brand of cigarettes. In the first experiment (Project 1a), behavioral and physiological responses to smoking cues will be evaluated using virtual reality cues. In addition, this experiment will assess changes in smoking severity via a dual-component self-administration session in conjunction with the CReSS device to assess smoking topography. In the second experiment (Project 1 b), functional magnetic resonance imaging will be used to measure brain responses to general reward, and to pictures of cigarettes and e-cigarettes. In addition, pictures displaying the Surgeon General's messages about cigarette smoking will be shown to evaluate perceptions about adverse health consequences of cigarettes and e-cigarettes. Upon completion of either laboratory-based experiment, all participants will proceed into the community-based study, project 2, in which all individuals (N=180) will be presented with e-cigarettes (18 mg). In this study, participants will visit the clinic once weekly for 4 week as well as 1 month follow-up. Daily assessments will be conducted using ecological momentary assessment (EMA). EMA assessments will include initiation and continuation of e-cigarette use, assessments of changes in use of own cigarettes, and assessments of perceptions, satisfaction and acceptability of e-cigarettes. Additionally, we will evaluate continuation of e-cigarette use a 1-month follow-up.

Public Health Relevance

This P30 application includes two key projects: project 1 will consist of two laboratory-based experiments and projects will be a community-based experiment. The proposed experiments will provide invaluable and detailed data to the FDA on e-cigarette initiation, use, multiple use, and perceptions in cigarette smokers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-RPHB-K (40))
Program Officer
Shafik, Hasnaa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Kundu, S T; Byers, L A; Peng, D H et al. (2016) The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. Oncogene 35:173-86
Treviño, Lindsey S; Bolt, Michael J; Grimm, Sandra L et al. (2016) Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK. Mol Endocrinol 30:158-72
Gargett, Tessa; Yu, Wenbo; Dotti, Gianpietro et al. (2016) GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade. Mol Ther 24:1135-49
Giudice, Jimena; Loehr, James A; Rodney, George G et al. (2016) Alternative Splicing of Four Trafficking Genes Regulates Myofiber Structure and Skeletal Muscle Physiology. Cell Rep 17:1923-1933
Li, Yiting; Nakka, Manjula; Kelly, Aaron J et al. (2016) p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res 76:4002-11
Ren, Yi A; Liu, Zhilin; Mullany, Lisa K et al. (2016) Growth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice. Biol Reprod 94:44
Oliver, Nora T; Hartman, Christine M; Kramer, Jennifer R et al. (2016) Statin drugs decrease progression to cirrhosis in HIV/HCV co-infected individuals. AIDS :
Aisiku, Imo P; Yamal, Jose-Miguel; Doshi, Pratik et al. (2016) Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury. Crit Care 20:288
Pethő, Zoltán; Tanner, Mark R; Tajhya, Rajeev B et al. (2016) Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Res Ther 18:103
Kwon, Oh-Joon; Zhang, Li; Xin, Li (2016) Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells 34:191-202

Showing the most recent 10 out of 683 publications