Recent data indicate dramatic increases in both awareness and use of electronic cigarettes (e-cigarettes) in the USA. Moreover, e-cigarette use is higher among current smokers than former- or never-smokers. This is of considerable public health significance since very little is known about the effects that e-cigarettes have on brain functioning, behavior, and physiology. This P30 application includes two key projects: project 1 will consist of two laboratory-based experiments and project 2 will be a community-based experiment. For the laboratory-based experiments, non-treatment seeking cigarette smokers (N=90/group) will be evaluated after exposure to e-cigarettes (0 or 18 mg) or their own cigarette on three separate visits: This will allow us to directly compare and evaluate e-cigarettes against smokers'preferred brand of cigarettes. In the first experiment (Project 1a), behavioral and physiological responses to smoking cues will be evaluated using virtual reality cues. In addition, this experiment will assess changes in smoking severity via a dual-component self-administration session in conjunction with the CReSS device to assess smoking topography. In the second experiment (Project 1 b), functional magnetic resonance imaging will be used to measure brain responses to general reward, and to pictures of cigarettes and e-cigarettes. In addition, pictures displaying the Surgeon General's messages about cigarette smoking will be shown to evaluate perceptions about adverse health consequences of cigarettes and e-cigarettes. Upon completion of either laboratory-based experiment, all participants will proceed into the community-based study, project 2, in which all individuals (N=180) will be presented with e-cigarettes (18 mg). In this study, participants will visit the clinic once weekly for 4 week as well as 1 month follow-up. Daily assessments will be conducted using ecological momentary assessment (EMA). EMA assessments will include initiation and continuation of e-cigarette use, assessments of changes in use of own cigarettes, and assessments of perceptions, satisfaction and acceptability of e-cigarettes. Additionally, we will evaluate continuation of e-cigarette use a 1-month follow-up.
This P30 application includes two key projects: project 1 will consist of two laboratory-based experiments and projects will be a community-based experiment. The proposed experiments will provide invaluable and detailed data to the FDA on e-cigarette initiation, use, multiple use, and perceptions in cigarette smokers.
|Addison, Joseph B; Koontz, Colton; Fugett, James H et al. (2015) KAP1 promotes proliferation and metastatic progression of breast cancer cells. Cancer Res 75:344-55|
|Torbit, Lindsey A; Albiani, Jenna J; Crangle, Cassandra J et al. (2015) Fear of recurrence: the importance of self-efficacy and satisfaction with care in gay men with prostate cancer. Psychooncology 24:691-8|
|Ramasamy, Ranjith; Ridgeway, Alex; Lipshultz, Larry I et al. (2014) Integrative DNA methylation and gene expression analysis identifies discoidin domain receptor 1 association with idiopathic nonobstructive azoospermia. Fertil Steril 102:968-973.e3|
|Kowalkowski, Marc A; Day, Rena S; Du, Xianglin L et al. (2014) Cumulative HIV viremia and non-AIDS-defining malignancies among a sample of HIV-infected male veterans. J Acquir Immune Defic Syndr 67:204-11|
|Thrift, Aaron P; Garcia, Jose M; El-Serag, Hashem B (2014) A multibiomarker risk score helps predict risk for Barrett's esophagus. Clin Gastroenterol Hepatol 12:1267-71|
|Bhattacharya, Abhisek; Parillon, Xyanthine; Zeng, Shenyan et al. (2014) Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis. J Biol Chem 289:26525-32|
|Thrift, Aaron P; Kramer, Jennifer R; Alsarraj, Abeer et al. (2014) Fat mass by bioelectrical impedance analysis is not associated with increased risk of Barrett esophagus. J Clin Gastroenterol 48:218-23|
|Geldres, Claudia; Savoldo, Barbara; Hoyos, Valentina et al. (2014) T lymphocytes redirected against the chondroitin sulfate proteoglycan-4 control the growth of multiple solid tumors both in vitro and in vivo. Clin Cancer Res 20:962-71|
|Young, Evelin; Zheng, Ze-Yi; Wilkins, Angela D et al. (2014) Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Mol Cell Biol 34:374-85|
|Anurathapan, Usanarat; Leen, Ann M; Brenner, Malcolm K et al. (2014) Engineered T cells for cancer treatment. Cytotherapy 16:713-33|
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