The overarching goal of the Cancer Biology Program, CBP, is to increase our understanding of the basic genetic, molecular, and biological mechanisms of cancer development and progression and to facilitate the translation of these findings for improved diagnostic, therapeutic, and preventative measures. The CBP consists of 51 Research Members, 14 Clinical Members, and 2 Adjunct Members. The membership spans 14 departments, and 2 centers, with two members from other institutions. The membership has $4.5 million in NCI funded research support out of a total of $30.6 million in total research support. The CBP program is highly productive with a total of 685 publications with 15% of the publications being intra-programmatic and 19% inter-programmatic. The program has been subdivided into 4 interdependent themes: Computational Biology, Functional Genomics, Cell Signaling, and Translation. The Computational Theme uses bioinformatic analyses of genomic, transcriptomic, proteomic, and metabolomic data to identify clinically relevant pathways for the development of therapeutic reagents or potential biomarkers to be moved to preclinical validation studies. The Functional Genomics Theme uses genetically engineered mouse models and patient-derived xenograft analysis to determine the significance of genetic alterations in human cancer as identified by the Computational Biology Theme. The Cell Signaling Theme functions to conduct in vitro mechanistic analysis of signaling pathways identified by the Computational and Functional Genomics Theme to determine how these pathways regulate cancer initiation, progression, and metastasis. The role of this group is to identify which pathways are targets for biomarkers or therapeutic development. Finally, the Translational Theme consists of clinical researchers and researchers involved in development of novel therapeutics. The goal of this Theme is to facilitate the translation of the basic science findings of the CBP to the patient. This group aids CBP researchers in determining how these findings can be translated to the development of therapies and biomarkers for the treatment of cancer.
Dan L. Duncan Cancer Center at Baylor College of Medicine OVERALL - PROJECT NARRATIVE Cancer is a leading cause of morbidity and mortality in the United States and globally. The diagnosis and treatment of cancer are extraordinarily demanding and increasingly expensive with major impacts on our economy. Although overall survival from cancer has improved and certain cancers can be prevented or cured, much remains to be accomplished to improve patient outcome through research to develop novel strategies to prevent, diagnose early, and effectively treat this disease. The Dan L. Duncan Cancer Center at Baylor College of Medicine has put together a strong multidisciplinary team of scientists, clinicians, educators, and community outreach experts to further improve survival from cancer both in our Catchment Area and globally, and to educate the scientists and clinicians of the future.
|Rohira, Aarti D; Yan, Fei; Wang, Lei et al. (2017) Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res 77:4293-4304|
|Woodard, Lauren E; Cheng, Jizhong; Welch, Richard C et al. (2017) Kidney-specific transposon-mediated gene transfer in vivo. Sci Rep 7:44904|
|Saxena, Kapil; Simon, Lukas M; Zeng, Xi-Lei et al. (2017) A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A 114:E570-E579|
|Heczey, Andras; Louis, Chrystal U; Savoldo, Barbara et al. (2017) CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma. Mol Ther 25:2214-2224|
|Schmueck-Henneresse, Michael; Omer, Bilal; Shum, Thomas et al. (2017) Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells. J Immunol 199:348-362|
|Ware, Matthew J; Nguyen, Lam P; Law, Justin J et al. (2017) A new mild hyperthermia device to treat vascular involvement in cancer surgery. Sci Rep 7:11299|
|Gibbons, Don L; Creighton, Chad J (2017) Pan-cancer survey of epithelial-mesenchymal transition markers across the Cancer Genome Atlas. Dev Dyn :|
|Ha, Kyungsoo; Ma, Chengxian; Lin, Han et al. (2017) The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun 8:15751|
|Shum, Thomas; Omer, Bilal; Tashiro, Haruko et al. (2017) Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells. Cancer Discov 7:1238-1247|
|Wang, Yongquan; Wang, Jianghua; Zhang, Li et al. (2017) RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression. Cancer Res 77:4247-4257|
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