Discovery and Developmental Therapeutics (DDT) Program is the primary driver of discovery and evaluation of novel therapeutic options for patients with cancer at the Winship Cancer Institute. The DDT Program has developed and recruited expertise focused on four specific interconnected goals: 1) to identify small molecule cancer therapeutics;2) to translate discoveries in cancer immunology into enhanced therapies;3) to develop innovative in vivo imaging technologies;and 4) to accelerate targeted therapeutics into clinical trials. DDT Program members pursue these goals In the lab and in clinic, providing numerous opportunities for dynamic collaboration both intra- and inter-programmatically. DDT members published 505 cancer-related publications in the current project period and demonstrated that they are active as well as interactive. Specifically, intra-programmatic publications account for 23% and inter-programmatic publications account for 25% of their total cancer-relevant publications. The DDT Program has met significant milestones in pursuing its goals by capitalizing on its members'strengths and the opportunities available to them. DDT's 52 core members represent 14 departments across Emory University, including the School of Medicine, the School of Public Health and Emory College. DDT members currently have $34,792,000 in research grant funding (annual direct costs), of which $24,711,747 is peer-reviewed and $12,405,796 is NCI funded. Scientific advances are made possible by access to outstanding shared resources, the opportunity to compete for various funding sources, and the provision of matching funds for large research grants. These opportunities, combined with capable leadership, will continue to enable the DDT Program to translate technologic advances into therapeutic options for patients with cancer.

Public Health Relevance

The Discovery and Developmental Therapeutics Program of the Winship Cancer Institute is the primary driver of discovery and evaluation of novel therapeutic options for patients with cancer seen at Winship.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
United States
Zip Code
Havel, L S; Kline, E R; Salgueiro, A M et al. (2015) Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity. Oncogene 34:1979-90
Forghani, Parvin; Khorramizadeh, Mohammad R; Waller, Edmund K (2014) Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer. Cancer Med 3:215-24
Smith, Alicia K; Conneely, Karen N; Pace, Thaddeus W W et al. (2014) Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy. Brain Behav Immun 38:227-36
Ha, Shin-Woo; Weitzmann, M Neale; Beck Jr, George R (2014) Bioactive silica nanoparticles promote osteoblast differentiation through stimulation of autophagy and direct association with LC3 and p62. ACS Nano 8:5898-910
Nooka, Ajay K; Johnson, Heather R; Kaufman, Jonathan L et al. (2014) Pharmacoeconomic analysis of palifermin to prevent mucositis among patients undergoing autologous hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 20:852-7
Capaldo, Christopher T; Farkas, Attila E; Hilgarth, Roland S et al. (2014) Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol Biol Cell 25:2710-9
Sullivan, Harold C; Oprea-Ilies, Gabriela; Adams, Amy L et al. (2014) Triple-negative breast carcinoma in African American and Caucasian women: clinicopathology, immunomarkers, and outcome. Appl Immunohistochem Mol Morphol 22:17-23
Brodie, Seth A; Li, Ge; El-Kommos, Adam et al. (2014) Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer. Cancer Prev Res (Phila) 7:351-61
Wang, Hongyan; Wang, Ya (2014) Heavier ions with a different linear energy transfer spectrum kill more cells due to similar interference with the Ku-dependent DNA repair pathway. Radiat Res 182:458-61
Jurchenko, Carol; Chang, Yuan; Narui, Yoshie et al. (2014) Integrin-generated forces lead to streptavidin-biotin unbinding in cellular adhesions. Biophys J 106:1436-46

Showing the most recent 10 out of 49 publications