The Cancer Cell Biology (CCB) Program of Winship Cancer Institute of Emory University is a laboratory-based translational program focused on understanding the changes in function of human cells as a result of cell transformation. Deregulation of the intra- and extra-cellular functional interactions of the cell's proteome leads to abnormal cell phenotypes, and these processes are at the root of the cancer process. The research within the CCB Program is organized into three scientific themes: (1) Cell Survival and Death Mechanisms, which focuses on intrinsic and extrinsic regulation of cell death through understanding and targeting both the Bcl-2 family and of death receptors; (2) Tumor?Stroma Interactions, which seeks to understand how tumor cells communicate and adhere, the biology of cancer stem cells, angiogenesis and immune interactions, and the process of EMT that is important for cell motility, invasion, and metastasis; and (3) Cancer Cell Metabolism, which focuses on how genetic alterations affecting signaling pathways impact the posttranslational modifications of key metabolic enzymes and redirect metabolic intermediates toward the synthesis of biomolecules of cell growth and proliferation. Under the leadership of Erwin Van Meir, PhD (leader) and Lawrence Boise, PhD (co-leader) the CCB Program has 36 core members from 16 different departments in the School of Medicine or Emory College. Between 2012 and the present, this highly collaborative group of researchers published 541 cancer- relevant scientific articles. Of these, 94 (17%) were intra- and 163 (30%) were inter-programmatic collaborations, and 214 (40%) involved a collaboration with another cancer center or academic organization. As of March 31, 2016, CCB held $17.7 million in annual total cancer-relevant research funding, of which $12.2 million (69%) was awarded directly from the NCI. The scientific advances driven by the CCB Program are highly significant in that they unravel novel mechanisms underlying cancer formation and growth and, in this process, unveil potential therapeutic targets.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA138292-10
Application #
9480804
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Xiao, Canhua; Beitler, Jonathan J; Higgins, Kristin A et al. (2018) Differential regulation of NF-kB and IRF target genes as they relate to fatigue in patients with head and neck cancer. Brain Behav Immun 74:291-295
Cassidy, Richard J; Zhang, Xinyan; Switchenko, Jeffrey M et al. (2018) Health care disparities among octogenarians and nonagenarians with stage III lung cancer. Cancer 124:775-784
Jhaveri, Jaymin; Chowdhary, Mudit; Zhang, Xinyan et al. (2018) Does size matter? Investigating the optimal planning target volume margin for postoperative stereotactic radiosurgery to resected brain metastases. J Neurosurg :1-7
Jhaveri, Jaymin; Rayfield, Lael; Liu, Yuan et al. (2018) Impact of intensity modulated radiation therapy on survival in anal cancer. J Gastrointest Oncol 9:618-630
Bilen, Mehmet Asim; Dutcher, Giselle Marie Almeida; Liu, Yuan et al. (2018) Association Between Pretreatment Neutrophil-to-Lymphocyte Ratio and Outcome of Patients With Metastatic Renal-Cell Carcinoma Treated With Nivolumab. Clin Genitourin Cancer 16:e563-e575
Chowdhary, Mudit; Switchenko, Jeffrey M; Press, Robert H et al. (2018) Post-treatment neutrophil-to-lymphocyte ratio predicts for overall survival in brain metastases treated with stereotactic radiosurgery. J Neurooncol 139:689-697
Lin, Songbai; Han, Yiran; Jenkin, Kayte et al. (2018) Lysophosphatidic Acid Receptor 1 Is Important for Intestinal Epithelial Barrier Function and Susceptibility to Colitis. Am J Pathol 188:353-366
Morgan, T M; Wang, X; Qian, X et al. (2018) Measurement of circulating tumor cells in squamous cell carcinoma of the head and neck and patient outcomes. Clin Transl Oncol :
Bekhbat, Mandakh; Chu, Karen; Le, Ngoc-Anh et al. (2018) Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression. Psychoneuroendocrinology 98:222-229
Zhu, Dan; Osuka, Satoru; Zhang, Zhaobin et al. (2018) BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation. Cancer Cell 33:1004-1016.e5

Showing the most recent 10 out of 331 publications