The Biostatistics Shared Resource (BSR) provides statistical support and services to the Hollings Cancer Center (HCC) investigators. Specific services include assistance with grant and trial development, data analysis, clinical trial review and monitoring and education. For grant and protocol development, the BSR nelps HCC investigators by assisting with defining aims and outcomes, selecting an appropriate study design, developing a statistical analysis plan, and performing sample size calculations to determine and justify the number of subjects or patients included in the study. The HCC BSR also actively assists with data analysis in a number of settings, including manuscript and abstract preparation, preliminary data for grant submissions, and for pilot projects supported by HCC. The faculty of the BSR participates in the HCC Protocol Review and Data and Safety Monitoring Committees providing critical review of trials and in providing educational opportunities to faculty, fellows, residents and staff of the HCC. There are currently four statisticians in the BSR. The BSR has provided services to all four HCC research programs presented in this application and to a developing program in cancer prevention and control. Since the new BSR Director was appointed in February 2007, usage of the BSR has increased dramatically. Thirty-seven grants have been submitted in the previous calendar year, and 27 manuscripts and abstracts submitted with the support of the BSR. These efforts demonstrate the current high utilization of the BSR by HCC investigators, and a strong commitment of the BSR to the research goals of the HCC. The specific purposes of the BSR are to: Collaborate with HCC investigators in study development, implementation, and publication by providing assistance with study design, statistical analysis plans, sample size considerations, statistical analysis, and grant and manuscript preparation Utilize, adapt and develop novel statistical methodologies, as needs arise, to respond to challenging research issues in ongoing HCC research Serve on clinical trial review and monitoring committees within the HCC providing critical reviews of proposed and ongoing internal and external clinical trials Provide ongoing education in statistical methods and approaches for members of the HCC

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Medical University of South Carolina
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Song, J H; An, N; Chatterjee, S et al. (2015) Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing. Oncogene 34:3728-36
Zemskova, Marina Y; Song, Jin H; Cen, Bo et al. (2015) Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cell Signal 27:135-46
Boppana, Nithin B; Kodiha, Mohamed; Stochaj, Ursula et al. (2014) Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. Photochem Photobiol Sci 13:1621-7
God, Jason M; Zhao, Dan; Cameron, Christine A et al. (2014) Disruption of HLA class II antigen presentation in Burkitt lymphoma: implication of a 47,000 MW acid labile protein in CD4+ T-cell recognition. Immunology 142:492-505
Fuseler, John W; Robichaux, Jacqulyne P; Atiyah, Huda I et al. (2014) Morphometric and fractal dimension analysis identifies early neoplastic changes in mammary epithelium of MMTV-cNeu mice. Anticancer Res 34:1171-7
Esnaola, Nestor F; Chaudhary, Uzair B; O'Brien, Paul et al. (2014) Phase 2 trial of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 88:837-44
Chen, Weiqin; Zhou, Hongyi; Saha, Pradip et al. (2014) Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology 155:4215-25
Hussey, Sophie E; Lum, Helen; Alvarez, Andrea et al. (2014) A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia 57:582-91
Kesarwani, Pravin; Al-Khami, Amir A; Scurti, Gina et al. (2014) Promoting thiol expression increases the durability of antitumor T-cell functions. Cancer Res 74:6036-47
He, Huacheng; Cattran, Alexander W; Nguyen, Tu et al. (2014) Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery. Biomaterials 35:9546-53

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