The scientific goal of the Cancer Genes &Molecular Regulation (CGMR) Program is to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins, and signaling pathways that mediate the altered phenotypes of cancer cells. The three themes are: ? Cancer Genomics &Genetics: discovery, validation, and elucidation of the mechanisms of action of genomic alterations in cancer. ? Molecular Regulation of Gene Expression: abnormalities in the regulation of RNA stability and function, the action of miRNAs, and post-transcriptional regulation of gene expression in malignancy. ? Cell &Tumor Biology: cell signaling pathways and stroma and matrix factors that influence both cancer cell growth and stem cell biology. The overall goals of the CGMR Program are to provide a scientific environment that: 1) promotes the ability of investigators from diverse disciplines to work together to develop an integrated understanding of the molecular mechanisms that drive critical cancer-associated alterations in normal cell growth, survival, and invasive potential;and 2) fosters the discovery, validation, and identification of potential therapeutic and preventive strategies. These goals are accomplished through a multi-level approach that includes monthly scientific meetings, special interest groups within the program, program-specific seminars, and targeted recruitment of faculty to enhance programmatic research, together with the development of critical new and/or enhanced shared research resources. Currently, the CGMR Program is composed of 24 members representing eight departments from within the College of Medicine, College of Pharmacy, and the College of Dental Medicine with more than $4.4M in extramural research funding ($4.3M in peer-reviewed projects;$2.8M from the NCI) and another $1.9M in program-related training and career development awards. In the last five years, program members produced 147 publications with 33% of these representing inter-programmatic and 31% intra-programmatic collaborations and 41% from multi-institutional collaborations.

Public Health Relevance

The Cancer Genes &Molecular Regulation Program members foster the development of cutting-edge cancer research focused on identifying novel cancer-regulating genes and evaluating their roles in cancer initiation, progression, and metastasis.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Medical University of South Carolina
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Link, Laura A; Howley, Breege V; Hussey, George S et al. (2016) PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res 14:634-46
Nelson, Michelle H; Bowers, Jacob S; Bailey, Stefanie R et al. (2016) Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. J Immunother Cancer 4:6
Podbielska, Maria; Szulc, Zdzisław M; Kurowska, Ewa et al. (2016) Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line. J Lipid Res 57:2028-2039
Sambandam, Yuvaraj; Sakamuri, Sashank; Balasubramanian, Sundaravadivel et al. (2016) RANK Ligand Modulation of Autophagy in Oral Squamous Cell Carcinoma Tumor Cells. J Cell Biochem 117:118-25
Miller, Kayla; Dixit, Suraj; Bredlau, Amy-Lee et al. (2016) Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine (Lond) 11:581-95
Basher, Fahmin; Jeng, Emily K; Wong, Hing et al. (2016) Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC. Oncotarget 7:814-30
Small, James; Flanagan, Catherine; Armeson, Kent et al. (2016) Family history of cutaneous and noncutaneous malignancies in relation to the risk of keratinocyte carcinoma coupled with another type of cancer: A case-control study. J Am Acad Dermatol 75:1066-1068.e7
Maldonado, Eduardo N; DeHart, David N; Patnaik, Jyoti et al. (2016) ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem 291:19642-50
Hendriks, Giel; Derr, Remco S; Misovic, Branislav et al. (2016) The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. Toxicol Sci 150:190-203
Paul, Matt R; Levitt, Nicholas P; Moore, David E et al. (2016) Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA. BMC Genomics 17:263

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