The scientific goal of the Cancer Genes &Molecular Regulation (CGMR) Program is to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins, and signaling pathways that mediate the altered phenotypes of cancer cells. The three themes are: ? Cancer Genomics &Genetics: discovery, validation, and elucidation of the mechanisms of action of genomic alterations in cancer. ? Molecular Regulation of Gene Expression: abnormalities in the regulation of RNA stability and function, the action of miRNAs, and post-transcriptional regulation of gene expression in malignancy. ? Cell &Tumor Biology: cell signaling pathways and stroma and matrix factors that influence both cancer cell growth and stem cell biology. The overall goals of the CGMR Program are to provide a scientific environment that: 1) promotes the ability of investigators from diverse disciplines to work together to develop an integrated understanding of the molecular mechanisms that drive critical cancer-associated alterations in normal cell growth, survival, and invasive potential;and 2) fosters the discovery, validation, and identification of potential therapeutic and preventive strategies. These goals are accomplished through a multi-level approach that includes monthly scientific meetings, special interest groups within the program, program-specific seminars, and targeted recruitment of faculty to enhance programmatic research, together with the development of critical new and/or enhanced shared research resources. Currently, the CGMR Program is composed of 24 members representing eight departments from within the College of Medicine, College of Pharmacy, and the College of Dental Medicine with more than $4.4M in extramural research funding ($4.3M in peer-reviewed projects;$2.8M from the NCI) and another $1.9M in program-related training and career development awards. In the last five years, program members produced 147 publications with 33% of these representing inter-programmatic and 31% intra-programmatic collaborations and 41% from multi-institutional collaborations.
The Cancer Genes &Molecular Regulation Program members foster the development of cutting-edge cancer research focused on identifying novel cancer-regulating genes and evaluating their roles in cancer initiation, progression, and metastasis.
|Barton, Virginia; Armeson, Kent; Hampras, Shalaka et al. (2017) Nonmelanoma skin cancer and risk of all-cause and cancer-related mortality: a systematic review. Arch Dermatol Res 309:243-251|
|Alexander-Bryant, Angela A; Zhang, Haiwen; Attaway, Christopher C et al. (2017) Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo. Oral Oncol 72:123-131|
|Kim, Sungjin; Alsaidan, Omar Awad; Goodwin, Octavia et al. (2017) Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression. Cancer Res 77:6950-6962|
|Yang, Aimin; Qin, Shenghui; Schulte, Bradley A et al. (2017) MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer. Cancer Res 77:6641-6650|
|Karam, Joseph A; Parikh, Rasesh Y; Nayak, Dhananjaya et al. (2017) Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis. J Biol Chem 292:6039-6046|
|Mehrotra, Shikhar; Britten, Carolyn D; Chin, Steve et al. (2017) Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer. J Hematol Oncol 10:82|
|Sagar, Amin; Arif, Ehtesham; Solanki, Ashish Kumar et al. (2017) Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function. Sci Rep 7:12047|
|Liu, Qinlong; Rehman, Hasibur; Krishnasamy, Yasodha et al. (2017) 8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. Int J Physiol Pathophysiol Pharmacol 9:69-83|
|Ghatak, Shibnath; Hascall, Vincent C; Markwald, Roger R et al. (2017) Transforming growth factor ?1 (TGF?1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis. J Biol Chem 292:10490-10519|
|Lemasters, John J (2017) Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis. Front Oncol 7:303|
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