The scientific goal of the Cancer Genes &Molecular Regulation (CGMR) Program is to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins, and signaling pathways that mediate the altered phenotypes of cancer cells. The three themes are: ? Cancer Genomics &Genetics: discovery, validation, and elucidation of the mechanisms of action of genomic alterations in cancer. ? Molecular Regulation of Gene Expression: abnormalities in the regulation of RNA stability and function, the action of miRNAs, and post-transcriptional regulation of gene expression in malignancy. ? Cell &Tumor Biology: cell signaling pathways and stroma and matrix factors that influence both cancer cell growth and stem cell biology. The overall goals of the CGMR Program are to provide a scientific environment that: 1) promotes the ability of investigators from diverse disciplines to work together to develop an integrated understanding of the molecular mechanisms that drive critical cancer-associated alterations in normal cell growth, survival, and invasive potential;and 2) fosters the discovery, validation, and identification of potential therapeutic and preventive strategies. These goals are accomplished through a multi-level approach that includes monthly scientific meetings, special interest groups within the program, program-specific seminars, and targeted recruitment of faculty to enhance programmatic research, together with the development of critical new and/or enhanced shared research resources. Currently, the CGMR Program is composed of 24 members representing eight departments from within the College of Medicine, College of Pharmacy, and the College of Dental Medicine with more than $4.4M in extramural research funding ($4.3M in peer-reviewed projects;$2.8M from the NCI) and another $1.9M in program-related training and career development awards. In the last five years, program members produced 147 publications with 33% of these representing inter-programmatic and 31% intra-programmatic collaborations and 41% from multi-institutional collaborations.

Public Health Relevance

The Cancer Genes &Molecular Regulation Program members foster the development of cutting-edge cancer research focused on identifying novel cancer-regulating genes and evaluating their roles in cancer initiation, progression, and metastasis.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Medical University of South Carolina
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Song, J H; An, N; Chatterjee, S et al. (2015) Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing. Oncogene 34:3728-36
Zemskova, Marina Y; Song, Jin H; Cen, Bo et al. (2015) Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cell Signal 27:135-46
Boppana, Nithin B; Kodiha, Mohamed; Stochaj, Ursula et al. (2014) Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. Photochem Photobiol Sci 13:1621-7
God, Jason M; Zhao, Dan; Cameron, Christine A et al. (2014) Disruption of HLA class II antigen presentation in Burkitt lymphoma: implication of a 47,000 MW acid labile protein in CD4+ T-cell recognition. Immunology 142:492-505
Esnaola, Nestor F; Chaudhary, Uzair B; O'Brien, Paul et al. (2014) Phase 2 trial of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 88:837-44
Fuseler, John W; Robichaux, Jacqulyne P; Atiyah, Huda I et al. (2014) Morphometric and fractal dimension analysis identifies early neoplastic changes in mammary epithelium of MMTV-cNeu mice. Anticancer Res 34:1171-7
Hussey, Sophie E; Lum, Helen; Alvarez, Andrea et al. (2014) A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia 57:582-91
Chen, Weiqin; Zhou, Hongyi; Saha, Pradip et al. (2014) Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology 155:4215-25
Kesarwani, Pravin; Al-Khami, Amir A; Scurti, Gina et al. (2014) Promoting thiol expression increases the durability of antitumor T-cell functions. Cancer Res 74:6036-47
He, Huacheng; Cattran, Alexander W; Nguyen, Tu et al. (2014) Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery. Biomaterials 35:9546-53

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