The scientific goal of the Cancer Immunology (Cl) Program at the Hollings Cancer Center (HCC) is to understand the basic mechanisms by which the immune system is regulated in cancer and to apply these discoveries to the development of immunotherapy trials. Led by Zihai Li, MD, PhD an immunologist and board-certified hematopoietic stem cell transplant physician, the Cl Program currently has 19 members representing 4 departments in the College of Medicine. Members hold 29 active grants (13 NCI) totaling $5.5M in annual total research project funding ($5.4M in peer-reviewed projects;$3.2M NCI), representing a 67% growth during this project period. The recruitment of 11 new scientists to the program since 2009 has greatly strengthened the breadth and depth of the science within the program. The three themes of the Cl Program are: ? Cancer Inflammation &Immune Tolerance: the role of inflammation and cross-talk between the innate and adaptive immune systems in cancer. ? T-Cell Biology &Therapy: T-cell mediated anti-tumor mechanisms and the development and optimization of novel cell-based therapies. ? Antibody, Complement, &Transplant-based Therapies: cross-cutting studies into antibody, complement, and transplant-based immunotherapeutic strategies. In the current funding period, the HCC Cl Program has clearly demonstrated success in nurturing groundbreaking basic research initiatives and has initiated several clinical applications from these findings. In the past five years, Cl Program members produced 119 cancer immunology-based publications with 29% of these representing inter-programmatic and 25% intra-programmatic collaborations and 45% from multiinstitutional collaborations.

Public Health Relevance

The Hollings Cancer Center's Cancer Immunology Program is composed of 19 scientists representing multiple biomedical disciplines who are working together to understand the biology of the immune system and its role in the development and progression of cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Medical University of South Carolina
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Link, Laura A; Howley, Breege V; Hussey, George S et al. (2016) PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res 14:634-46
Nelson, Michelle H; Bowers, Jacob S; Bailey, Stefanie R et al. (2016) Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. J Immunother Cancer 4:6
Podbielska, Maria; Szulc, Zdzisław M; Kurowska, Ewa et al. (2016) Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line. J Lipid Res 57:2028-2039
Sambandam, Yuvaraj; Sakamuri, Sashank; Balasubramanian, Sundaravadivel et al. (2016) RANK Ligand Modulation of Autophagy in Oral Squamous Cell Carcinoma Tumor Cells. J Cell Biochem 117:118-25
Miller, Kayla; Dixit, Suraj; Bredlau, Amy-Lee et al. (2016) Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine (Lond) 11:581-95
Basher, Fahmin; Jeng, Emily K; Wong, Hing et al. (2016) Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC. Oncotarget 7:814-30
Small, James; Flanagan, Catherine; Armeson, Kent et al. (2016) Family history of cutaneous and noncutaneous malignancies in relation to the risk of keratinocyte carcinoma coupled with another type of cancer: A case-control study. J Am Acad Dermatol 75:1066-1068.e7
Maldonado, Eduardo N; DeHart, David N; Patnaik, Jyoti et al. (2016) ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem 291:19642-50
Hendriks, Giel; Derr, Remco S; Misovic, Branislav et al. (2016) The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. Toxicol Sci 150:190-203
Paul, Matt R; Levitt, Nicholas P; Moore, David E et al. (2016) Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA. BMC Genomics 17:263

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