The scientific goal of the Cancer Immunology (Cl) Program at the Hollings Cancer Center (HCC) is to understand the basic mechanisms by which the immune system is regulated in cancer and to apply these discoveries to the development of immunotherapy trials. Led by Zihai Li, MD, PhD an immunologist and board-certified hematopoietic stem cell transplant physician, the Cl Program currently has 19 members representing 4 departments in the College of Medicine. Members hold 29 active grants (13 NCI) totaling $5.5M in annual total research project funding ($5.4M in peer-reviewed projects;$3.2M NCI), representing a 67% growth during this project period. The recruitment of 11 new scientists to the program since 2009 has greatly strengthened the breadth and depth of the science within the program. The three themes of the Cl Program are: ? Cancer Inflammation &Immune Tolerance: the role of inflammation and cross-talk between the innate and adaptive immune systems in cancer. ? T-Cell Biology &Therapy: T-cell mediated anti-tumor mechanisms and the development and optimization of novel cell-based therapies. ? Antibody, Complement, &Transplant-based Therapies: cross-cutting studies into antibody, complement, and transplant-based immunotherapeutic strategies. In the current funding period, the HCC Cl Program has clearly demonstrated success in nurturing groundbreaking basic research initiatives and has initiated several clinical applications from these findings. In the past five years, Cl Program members produced 119 cancer immunology-based publications with 29% of these representing inter-programmatic and 25% intra-programmatic collaborations and 45% from multiinstitutional collaborations.

Public Health Relevance

The Hollings Cancer Center's Cancer Immunology Program is composed of 19 scientists representing multiple biomedical disciplines who are working together to understand the biology of the immune system and its role in the development and progression of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA138313-06
Application #
8695803
Study Section
Subcommittee G - Education (NCI)
Project Start
2009-04-01
Project End
2019-03-31
Budget Start
2014-06-20
Budget End
2015-03-31
Support Year
6
Fiscal Year
2014
Total Cost
$30,753
Indirect Cost
$10,213
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29403
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Zemskova, Marina Y; Song, Jin H; Cen, Bo et al. (2015) Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cell Signal 27:135-46
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