The scientific goal of the Cancer Control (CC) Program is to foster population-based research that will lead to a reduction in cancer morbidity and mortality in South Carolina (SC) while providing scientific evidence and novel cancer control interventions that can be applied beyond the state's borders. The CC Program investigators have made substantive progress toward this goal primarily through focused research efforts in two major themes - generating novel insights and approaches to tobacco control and addressing cancer health disparities. Within these two themes, the CC Program members work collaboratively to conduct and link research that identifies behavioral risk factors predisposing individuals to cancer development and to translate these findings into cost effective, sustainable interventions to modify risk factors. Furthermore, the CC Program members are working with government and community leaders to disseminate these evidence based strategies to impact the cancer burden in SC. Currently, the CC Program consists of 23 members representing 11 departments from within the College of Medicine, College of Nursing and the College of Pharmacy with more than $4.6M in peer-reviewed extramural research funding ($1.6M from the NCI) and another $640K in program-supportive training and career development awards. In the past five years, program members produced 170 publications with 17% of these representing inter-programmatic and 29% intra-programmatic collaborations, and 57% from multi-institutional collaborations.
The Hollings Cancer Center's Cancer Control Program conducts population-based research focused on reducing cancer morbidity and mortality in South Carolina while providing scientific evidence and novel cancer control interventions that can be applied beyond the state's borders.
|Barton, Virginia; Armeson, Kent; Hampras, Shalaka et al. (2017) Nonmelanoma skin cancer and risk of all-cause and cancer-related mortality: a systematic review. Arch Dermatol Res 309:243-251|
|Alexander-Bryant, Angela A; Zhang, Haiwen; Attaway, Christopher C et al. (2017) Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo. Oral Oncol 72:123-131|
|Kim, Sungjin; Alsaidan, Omar Awad; Goodwin, Octavia et al. (2017) Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression. Cancer Res 77:6950-6962|
|Yang, Aimin; Qin, Shenghui; Schulte, Bradley A et al. (2017) MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer. Cancer Res 77:6641-6650|
|Karam, Joseph A; Parikh, Rasesh Y; Nayak, Dhananjaya et al. (2017) Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis. J Biol Chem 292:6039-6046|
|Mehrotra, Shikhar; Britten, Carolyn D; Chin, Steve et al. (2017) Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer. J Hematol Oncol 10:82|
|Sagar, Amin; Arif, Ehtesham; Solanki, Ashish Kumar et al. (2017) Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function. Sci Rep 7:12047|
|Liu, Qinlong; Rehman, Hasibur; Krishnasamy, Yasodha et al. (2017) 8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. Int J Physiol Pathophysiol Pharmacol 9:69-83|
|Ghatak, Shibnath; Hascall, Vincent C; Markwald, Roger R et al. (2017) Transforming growth factor ?1 (TGF?1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis. J Biol Chem 292:10490-10519|
|Lemasters, John J (2017) Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis. Front Oncol 7:303|
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