Detailed program planning and rigorous, continuing evaluation has been critical for the development of the research infrastructure at the Hollings Cancer Center (HCC). They are based on multiple feedback mechanisms and both external and internal review. The HCC External Scientific Advisory Board is the primary external mechanism for review and advice on the HCC's progress in research. Internal mechanisms include the advice and counsel of HCC's associate directors who formally comprise the HCC Executive Council;the HCC Research Committee, which combines the leadership of the associate directors and program leaders;an Internal Institutional Advisory Committee that meets annually and includes MUSC leaders and officials;and a Clinical Research Resource Committee encompassing multidisciplinary clinical leadership who are critical to the HCC's clinical research enterprise. Other planning and evaluation efforts occur at the program and shared resource levels and are essential to the strength of the Center. A critical element of the planning process is the written strategic plan. Dr. Kraft and the Center's leadership updated this strategic plan in 2009 to guide the development of the HCC over the current CCSG project period. This plan identified: 1) The need to expand services within existing shared research resources as well as create new shared research resources;2) Organizational strategies to improve collaboration, interdisciplinary interactions, and educational efforts;and 3) Targeted faculty recruitment to expand the depth and breadth of the HCC research base. It also identified nine strategic focus areas for research development. This 2009-2013 strategic plan has regularly been re-visited, reviewed for progress, and updated with the input of the HCC's leadership team. The vast majority of the strategic plan has been accomplished, and an updated 2014-2018 plan is underdevelopment

Public Health Relevance

The ongoing, clearly-defined, formative and summative evaluation and planning processes of the Hollings Cancer Center are key to its unprecedented growth and sustained excellence in performance as indicated by achievement of benchmarks of success in all aspects of its mission.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
United States
Zip Code
Song, J H; An, N; Chatterjee, S et al. (2015) Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing. Oncogene 34:3728-36
Zemskova, Marina Y; Song, Jin H; Cen, Bo et al. (2015) Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cell Signal 27:135-46
Boppana, Nithin B; Kodiha, Mohamed; Stochaj, Ursula et al. (2014) Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. Photochem Photobiol Sci 13:1621-7
God, Jason M; Zhao, Dan; Cameron, Christine A et al. (2014) Disruption of HLA class II antigen presentation in Burkitt lymphoma: implication of a 47,000 MW acid labile protein in CD4+ T-cell recognition. Immunology 142:492-505
Esnaola, Nestor F; Chaudhary, Uzair B; O'Brien, Paul et al. (2014) Phase 2 trial of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 88:837-44
Fuseler, John W; Robichaux, Jacqulyne P; Atiyah, Huda I et al. (2014) Morphometric and fractal dimension analysis identifies early neoplastic changes in mammary epithelium of MMTV-cNeu mice. Anticancer Res 34:1171-7
Hussey, Sophie E; Lum, Helen; Alvarez, Andrea et al. (2014) A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia 57:582-91
Chen, Weiqin; Zhou, Hongyi; Saha, Pradip et al. (2014) Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology 155:4215-25
Kesarwani, Pravin; Al-Khami, Amir A; Scurti, Gina et al. (2014) Promoting thiol expression increases the durability of antitumor T-cell functions. Cancer Res 74:6036-47
He, Huacheng; Cattran, Alexander W; Nguyen, Tu et al. (2014) Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery. Biomaterials 35:9546-53

Showing the most recent 10 out of 162 publications