One of the highest priorities of the Simmons Cancer Center is to efficiently translate scientific discoveries to the clinic in order to reduce cancer morbidity and mortality. U.T. Southwestem has a long tradition of excellence in the basic sciences and with the recent organization of well-defined Cancer Center programs, institutional scientists are responsible for some of the most important recent advances in translatable cancer biology. Early phase Investigator-initiated translational research trials require significant regulatory, data management and research nursing resources that are not always available through traditional mechanisms in a timely fashion. Protocol-specific research support provides a mechanism for rapidly translating institutional cancer science to the clinic. These funds are intended to support the programmatic priorities of the Simmons Cancer Center. Criteria used to assess suitability for Protocol-Specific Research support include: 1. Investigator-initiated feasibility/Phase I or pilot trial with exceptional scientific merit 2. The trial must meet one or more of the following criteria: a. The agent or concept to be tested is a product of U.T. Southwestern preclinical science. b. The trial will generate data required for external peer-reviewed funding or for development into a larger, multi-institutional phase II or III trial. c. The trial promotes significant interaction between basic and clinical scientists to achieve important correlative objectives. Priorities for this funding are communicated to the Disease Oriented Teams (DOTs) through the bi-monthly DOT leaders meetings and to the Program Leaders at their bi-monthly meetings. Information flows both directions at these meetings as DOT leaders can vet investigator initiated protocol ideas and Program leaders can promote agents or molecules ready for clinical evaluation. Individual DOTs are encouraged to develop and refine protocol concepts responsive to the Cancer Center priorities and to seek feedback from the Associate Director for Clinical Research early in the development process.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA142543-04
Application #
8519969
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$40,504
Indirect Cost
$27,466
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Huang, Xiumei; Motea, Edward A; Moore, Zachary R et al. (2016) Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors. Cancer Cell 30:940-952
Singal, Amit G; Gupta, Samir; Tiro, Jasmin A et al. (2016) Outreach invitations for FIT and colonoscopy improve colorectal cancer screening rates: A randomized controlled trial in a safety-net health system. Cancer 122:456-63
Knudsen, Erik S; O'Reilly, Eileen M; Brody, Jonathan R et al. (2016) Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine. Gastroenterology 150:48-63
Gallardo-Montejano, Violeta I; Saxena, Geetu; Kusminski, Christine M et al. (2016) Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function. Nat Commun 7:12723
Skinner, Celette Sugg; Gupta, Samir; Halm, Ethan A et al. (2016) Development of the Parkland-UT Southwestern Colonoscopy Reporting System (CoRS) for evidence-based colon cancer surveillance recommendations. J Am Med Inform Assoc 23:402-6
McNamara, Ryan P; Reeder, Jonathan E; McMillan, Elizabeth A et al. (2016) KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II. Mol Cell 61:39-53
Belfatto, Antonella; White, Derek A; Mason, Ralph P et al. (2016) Tumor radio-sensitivity assessment by means of volume data and magnetic resonance indices measured on prostate tumor bearing rats. Med Phys 43:1275-84
Wylie, Annika; Jones, Amanda E; D'Brot, Alejandro et al. (2016) p53 genes function to restrain mobile elements. Genes Dev 30:64-77
Fernando, W Shirangi; Martins, André F; Zhao, Piyu et al. (2016) Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents. Inorg Chem 55:3007-14
Singal, Amit G; Tiro, Jasmin A; Marrero, Jorge A et al. (2016) Mailed Outreach Program Increases Ultrasound Screening of Patients with Cirrhosis for Hepatocellular Carcinoma. Gastroenterology :

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