Our current understanding of human cancers highlights the importance of aberrant developmental programs in cancer pathogenesis. The Development and Cancer Scientific Program (DCSP) brings together invesfigators in the related fields of cancer biology, stem cell biology and developmental biology as a means of exploiting and focusing upon cancer the diverse strengths at UT Southwestern (UTSW) in developmental biology. The three scientific goals of the program are to: 1) Define the interactions between malignant tumor cells and their local environment: Clinicians have long appreciated that particular tumors metastasize to particular sites, suggesfing that tumor cells depend upon specific interactions with normal tissues for their establishment, growth and survival. In addition, epidemiological evidence suggests that other host factors such as obesity are linked with increased cancer risk, through unknown mechanisms. Emerging discoveries are beginning to highlight interacfions between cancer cells and normal host tissues, and a major goal of the DCSP is to define these host-tumor cell interactions at a molecular level with the goal of developing novel and more effective treatments. Program interest is focused in three areas: adiposity and breast cancer, host-tumor interacfion in gliomagenesis and neurofibromatosis, and targefing tumor vasculature. 2) Reveal the molecular mechanisms that confer upon stem cells and cancer stem cells their unique and remarkable properties of self-renewal and pluripotency: There is growing expertise in stem cell biology at UTSW that is harnessed within the program to define the genefic, epigenefic and cell-signaling mechanisms that confer upon stem cells and cancer stem cells their essential characterisfics of pluripotency and capacity for self-renewal. Within the broader research topics represented in the Scientific Programs, the particular strength of the DCSP is its focus on study in living animals, including mouse models. 3) Enhance scientific interactions between clinical investigators and basic scientists to stimulate cancer-focused basic research and clinical translation of research discoveries: Insights revealed by basic research drive new approaches towards cancer treatment, and clinical observations and materials provide opportunifies for important discoveries that will improve treatment of cancer. Physician-scientists within the DCSP are leading projects that focus upon in vivo models of cancer, and choose their research questions with first-hand knowledge of clinical relevance. The Cancer Center leadership and the DCSP lower the acfivation energy of productive interacfion between clinical invesfigators and basic scientists to generate cancer-focused discoveries.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA142543-05
Application #
8711032
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
$23,704
Indirect Cost
$1,856
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Eskiocak, Banu; McMillan, Elizabeth A; Mendiratta, Saurabh et al. (2017) Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma. Cancer Discov 7:832-851
Rutkowski, Joseph M; Pastor, Johanne; Sun, Kai et al. (2017) Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression. Kidney Int 91:324-337
Singh, Jaspal; Rustagi, Vineeta; Zhang, Shanrong et al. (2017) On-bead combinatorial synthesis and imaging of europium(III)-based paraCEST agents aids in identification of chemical features that enhance CEST sensitivity. Magn Reson Chem 55:747-753
Singh, Dinesh K; Kollipara, Rahul K; Vemireddy, Vamsidara et al. (2017) Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Cell Rep 18:961-976
Gu, Yi-Feng; Cohn, Shannon; Christie, Alana et al. (2017) Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade. Cancer Discov 7:900-917
Lee, Ming Y; Sumpter Jr, Rhea; Zou, Zhongju et al. (2017) Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep 18:48-60
Gao, Boning; Huang, Chunxian; Kernstine, Kemp et al. (2017) Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget 8:11114-11126
Howard, James J; Sturge, Carolyn R; Moustafa, Dina A et al. (2017) Inhibition of Pseudomonas aeruginosa by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother 61:
Skinner, Celette Sugg; Ahn, Chul; Halm, Ethan A et al. (2017) Recommendation of colorectal cancer testing among primary care patients younger than 50 with elevated risk. Prev Med 102:20-23
Garcia, Sandra; Bisen, Ajit; Yan, Jingsheng et al. (2017) Thoracic Oncology Clinical Trial Eligibility Criteria and Requirements Continue to Increase in Number and Complexity. J Thorac Oncol 12:1489-1495

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