The Cancer Control and Population Health (CCPH) program is a relatively new program within the Kansas University Cancer Center, developed explicitly to identify better ways to bring cancer control efforts into high risk and underserved communities. The CCPH program is co-led by Edward F. Ellerbeck, MD, MPH and Kimberly K. Engelman, PhD and brings together an interdisciplinary team of researchers focused on 1) advancing the science of working with underserved communities in efforts to improve cancer control and reduce cancer-related health disparities;2) identifying new strategies to improve smoking cessation and enhance the delivery of effective smoking cessation services;and 3) developing and testing novel methods to improve the delivery and uptake of effective cancer screening services. Since the creation of the CCPH, program members have made remarkable progress in developing the infrastructure to conduct cancer control research in underserved, regional rural, American Indian, African American, and Latino communities. Paralleling this growth in infrastructure has been a rapid growth in cancer control funding and an increase in program membership. CCPH program activities support both intra- and inter-programmatic interactions through translational research seminars, a visiting scholars program, research symposia, and research interest groups. A strong mentoring program has helped junior faculty procure training grants and minority supplements. CCPH research efforts have led to new discoveries related to the treatment of African American light smokers and the integration of smoking cessation efforts into rural primary care. Applying community based participatory research methods, CCPH researchers developed the first culturally tailored smoking cessation program designed for a heterogeneous American Indian community. The community-based research in the CCPH is strongly supported by a vibrant rural practice-based research network, the American Indian Health Research and Education Alliance, and the Latino Health Initiatives Network. This support has allowed CCPH members to enroll more than 10,000 people from underserved communities into cancer control research studies over the past 5 years. The 23 members of the CCPH program come from 5 departments in 2 schools. Although many members are new to cancer control research, they represent a rich mix of expertise, including psychologists, sociologists, neuroscientists, primary care physicians, oncologists, epidemiologists, biostatisticians, anthropologists, economists, pharmacists, communication specialists, and health services researchers. Program members are supported by $11.5 million in total annual funds, including $3.6 million from the National Cancer Institute. CCPH members have published 131 articles since 2006 of which 53 (40%) were intra-programmatic and 38 (29%) were inter-programmatic. In addition, CCPH members have accounted for 52.23% of the usage of the Biostatistics &Informatics Shared Resource and 9.6% of the Biospecimen Shared Resource.
The Cancer Control and Population Health program is identifying better ways to engage high risk and underserved communities in cancer control efforts. Members of this program are focused on advancing implementation science related to cancer screening and developing better techniques to reduce tobacco consumption.
|Jiang, Yu; Simon, Steve; Mayo, Matthew S et al. (2015) Modeling and validating Bayesian accrual models on clinical data and simulations using adaptive priors. Stat Med 34:613-29|
|Zeineldin, Maged; Jensen, Derek; Paranjape, Smita R et al. (2014) Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis. Genetics 197:1365-76|
|Winham, Stacey J; Armasu, Sebastian M; Cicek, Mine S et al. (2014) Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer. Genet Epidemiol 38:457-66|
|Block, Matthew S; Charbonneau, Bridget; Vierkant, Robert A et al. (2014) Variation in NF-?B signaling pathways and survival in invasive epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 23:1421-7|
|Pessetto, Ziyan Y; Ma, Yan; Hirst, Jeff J et al. (2014) Drug repurposing identifies a synergistic combination therapy with imatinib mesylate for gastrointestinal stromal tumor. Mol Cancer Ther 13:2276-87|
|Purrington, Kristen S; Slager, Susan; Eccles, Diana et al. (2014) Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis 35:1012-9|
|Bohl, Christopher R; Harihar, Sitaram; Denning, Warren L et al. (2014) Metastasis suppressors in breast cancers: mechanistic insights and clinical potential. J Mol Med (Berl) 92:13-30|
|Peterson, Kenneth R; Costa, Flávia C; Fedosyuk, Halyna et al. (2014) A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies. PLoS One 9:e107006|
|Meneely, Kathleen M; Luo, Qianyi; Riley, Andrew P et al. (2014) Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorg Med Chem 22:5961-9|
|Osorio, Ana; Milne, Roger L; Kuchenbaecker, Karoline et al. (2014) DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. PLoS Genet 10:e1004256|
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