The Integrative Pharmacology Core is very active in supporting direct experimentation and in providing other (theoretical/statistical) support services with colleagues both within Temple. University and externally. Studies with combinations of drugs of abuse represented a major activity of the Core. It continues to provide expertise in in vivo pharmacology and drug interaction studies to faculty, technicians, graduate and medical students at Temple University School of Medicine and externally. Beyond Temple, the comprehensive nature of the testing procedures has attracted collaborative interactions over the past 5 years. The Core offers pharmacological testing services for numerous endpoints in mice and/or rat, including: a neurological screen for overt behavior; tests for motor coordination; automatic monitoring of ambulation and stereotypies; analgesic/tolerance tests for acute, persistent and incisional pain; anti-inflammatory activity; antipruritic activity; body and brain temperature measurement; physical dependence/withdrawal; diuresis; oximetry; and stomach emptying, intestinal and colonic transit. The Core personnel also train and/or assist with various techniques such as icv drug administration, microinjection into specific brain nuclei, and microdialysis in various brain sites. In addition, the Core assists in experimental design and data analysis of various drug combinations. This Core has been well utilized by numerous Temple faculty members as well scientists outside of Temple. The services performed by the Core have enabled many investigators without prior experience in in vivo testing to add another dimension to their work without dramatically increasing their budgets. This factor has resulted in new collaborations, sparking novel approaches to solving age-old problems of tolerance and dependence, and innovative ideas for therapeutics. Over the following 5 years, the Integrative Core will be used to evaluate and characterize novel compounds in standard in vivo screens; to improve/develop existing procedures in tune with advancing technology; to provide training in a variety of techniques; to assist in conducting in vivo studies for laboratories that do not normally do such testing; and to collaborate in new research projects both within and without Temple University.
The Integrative Pharmacology Core has aided investigators doing cutting edge research to extend their investigations to include animal models, new research design methods, and drug interaction studies. Training is provided to junior faculty, graduate students, and postdoctoral fellows. New approaches to studying drug interactions have been put forth. New hypotheses have resulted from this work, including the proposal that chemokines are a third major transmitter system in the brain.
|Bogush, Marina; Heldt, Nathan A; Persidsky, Yuri (2017) Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition. J Neuroimmune Pharmacol 12:593-601|
|Howlett, Allyn C; Abood, Mary E (2017) CB1 and CB2 Receptor Pharmacology. Adv Pharmacol 80:169-206|
|Mooney, James; Rawls, Scott M (2017) KCNQ2/3 channel agonist flupirtine reduces cocaine place preference in rats. Behav Pharmacol 28:405-407|
|Kim, Jae; Connelly, Krista L; Unterwald, Ellen M et al. (2017) Chemokines and cocaine: CXCR4 receptor antagonist AMD3100 attenuates cocaine place preference and locomotor stimulation in rats. Brain Behav Immun 62:30-34|
|Gherghina, Florin Liviu; Tica, Andrei Adrian; Deliu, Elena et al. (2017) Effects of VPAC1 activation in nucleus ambiguus neurons. Brain Res 1657:297-303|
|Brailoiu, G Cristina; Deliu, Elena; Barr, Jeffrey L et al. (2017) HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens. Drug Alcohol Depend 178:7-14|
|Fakhouri, Lara; Cook, Christopher D; Al-Huniti, Mohammed H et al. (2017) Design, synthesis and biological evaluation of GPR55 agonists. Bioorg Med Chem 25:4355-4367|
|Merkel, Steven F; Andrews, Allison M; Lutton, Evan M et al. (2017) Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells. J Neurochem 140:216-230|
|Merkel, Steven F; Cannella, Lee Anne; Razmpour, Roshanak et al. (2017) Factors affecting increased risk for substance use disorders following traumatic brain injury: What we can learn from animal models. Neurosci Biobehav Rev 77:209-218|
|Philogene-Khalid, Helene L; Hicks, Callum; Reitz, Allen B et al. (2017) Synthetic cathinones and stereochemistry: S enantiomer of mephedrone reduces anxiety- and depressant-like effects in cocaine- or MDPV-abstinent rats. Drug Alcohol Depend 178:119-125|
Showing the most recent 10 out of 321 publications