The mission of the Administrative and Theory (A&T) Core is to facilitate research by the 20 members, 5 trainees, and 38 funded projects that comprise the Duke Transdisciplinary Prevention Research Center (TPRC).
Six aims guide this Core, The first aim is to sustain and expand our multi-disciplinary intellectual community devoted to translational science in adolescent substance use prevention. During our initial tenure as a P20 Center, we have assembled faculty members from 8 administrative departments and 7 disciplines into a genuine community of scholars, the community will be nurtured by multi-disciplinary working groups, an active lunch bunch series, nationally prominent visiting speakers, meetings of advisory boards, an annual day-long retreat, an inviting physical location for investigators to congregate, a regular newsletter, research briefs, and a website.
The second aim i s to cultivate innovative theory about the development and prevention of adolescent substance use.
This aim will be accomplished through a Faculty Fellows Seminar, in which 6 to 8 investigators across disciplines will commit to meet regularly to discuss a common theme or topic (e.g., methods to assess change, commonalities in regulatory process across levels, gene-environment interaction), for the purposes of developing collaborative research studies within the funded projects and proposing new projects.
The third aim i s to facilitate cross-project collaboration by assembling time-limited work groups composed of investigators from projects that share a common theme (e.g., the longitudinal studies of members Moffitt, Caspi, Dodge, Costello, Burton, Strauman, and Costanzo). Members of these work groups will meet regularly to consider common theory-testing, measurement, methods, or data analyses.
The fourth aim i s to nurture the training and career development of junior investigators, through participation in Core activities and support for career development awards and training programs. The fifth aim is to facilitate the administration and grants management of the funded, pending, and planned projects.
The final aim i s to evaluate the TPRC, through annual systematic surveys and an external review. The Administrative and Theory Core of the Duke Transdisciplinary Prevention Research Center will reduce the public health burden of adolescent substance use by supporting multi-disciplinary efforts by investigators to develop innovative theories and programs to prevent substance use.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Center Core Grants (P30)
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Special Emphasis Panel (ZDA1-RXL-E)
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Duke University
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Hill, Sherika; Shanahan, Lilly; Costello, E Jane et al. (2017) Predicting Persistent, Limited, and Delayed Problematic Cannabis Use in Early Adulthood: Findings From a Longitudinal Study. J Am Acad Child Adolesc Psychiatry 56:966-974.e4
Golonka, Megan M; Peairs, Kristen F; Malone, Patrick S et al. (2017) Natural Peer Leaders as Substance Use Prevention Agents: the Teens' Life Choice Project. Prev Sci 18:555-566
Okado, Yuko; Ewing, Emily; Rowley, Christina et al. (2017) Trajectories of Mental Health-Related Service Use Among Adolescents With Histories of Early Externalizing Problems. J Adolesc Health 61:198-204
Swartz, Johnna R; Prather, Aric A; Di Iorio, Christina R et al. (2017) A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men. Neuropsychopharmacology 42:419-426
Scult, Matthew A; Knodt, Annchen R; Hanson, Jamie L et al. (2017) Individual differences in regulatory focus predict neural response to reward. Soc Neurosci 12:419-429
Copeland, William E; Hill, Sherika; Costello, E Jane et al. (2017) Cannabis Use and Disorder From Childhood to Adulthood in a Longitudinal Community Sample With American Indians. J Am Acad Child Adolesc Psychiatry 56:124-132.e2
Scult, Matthew A; Knodt, Annchen R; Swartz, Johnna R et al. (2017) Thinking and Feeling: Individual Differences in Habitual Emotion Regulation and Stress-Related Mood are Associated with Prefrontal Executive Control. Clin Psychol Sci 5:150-157
Swartz, Johnna R; Knodt, Annchen R; Radtke, Spenser R et al. (2017) Peering into the brain to predict behavior: Peer-reported, but not self-reported, conscientiousness links threat-related amygdala activity to future problem drinking. Neuroimage 146:894-903
Strauman, Timothy J; Eddington, Kari M (2017) Treatment of Depression From a Self-Regulation Perspective: Basic Concepts and Applied Strategies in Self-System Therapy. Cognit Ther Res 41:1-15
Dotterer, Hailey L; Hyde, Luke W; Swartz, Johnna R et al. (2017) Amygdala reactivity predicts adolescent antisocial behavior but not callous-unemotional traits. Dev Cogn Neurosci 24:84-92

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