Under the direction of Rick Hoyle, the primary objectives of the Methodology and Statistics Core in the Duke Transdisciplinary Prevention Research Center (TPRC) are to facilitate, encourage, strengthen, and expand the quality of collection, management, and analysis of data in research on the prevention of adolescent substance abuse. The Core will provide resources and expertise that contribute to the development, execution, analysis, and publication of high quality prevention science focused on adolescent substance abuse. The Core will ensure professional quality consultation and collaborative opportunities as specified in the following aims. 1. Provide leadership in the application of rigorous and innovative statistical methods in TPRC research. 2. Provide data-warehousing functions that include data management;storage and retrieval of electronic data;and quality control and assurance of electronic data. 3. Expand advanced data-analytic services offered by the Core to meeting the varied and emerging needs of TPRC investigators. 4. Promote methodological and statistical education and training opportunities for TPRC investigators and the broader community of prevention scientists at Duke and UNC.
These aims will be pursued by a multidisciplinary team of experts who are experienced providers of methodological and statistical support for complex, large-scale, funded research projects. The Methodology and Statistics Core will provide a crucial link between the network of prevention scientists at Duke and the methodologists and statisticians distributed across units at the institution. In addition, the Methodology and Statistics Core will offer leadership to the broader substance abuse prevention research effort by providing training and technology transfer in the application of state-of-the-art statistical methods, providing a readily accessible structure for interdisciplinary sharing of ideas, and training graduate students and postdoctoral fellows in prevention science methods. The Methodology and Statistics Core of the Duke Transdisciplinary Prevention Research Center will reduce the public health burden of adolescent substance use by enhancing the capacity of investigators to analyze their data in ways that facilitate novel prevention programs and activities.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Center Core Grants (P30)
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Special Emphasis Panel (ZDA1-RXL-E)
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Duke University
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Gorka, Adam X; LaBar, Kevin S; Hariri, Ahmad R (2016) Variability in emotional responsiveness and coping style during active avoidance as a window onto psychological vulnerability to stress. Physiol Behav 158:90-9
Zheng, Yao; Albert, Dustin; McMahon, Robert J et al. (2016) Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. Prev Sci :
Hanson, Jamie L; Albert, Dustin; Iselin, Anne-Marie R et al. (2016) Cumulative stress in childhood is associated with blunted reward-related brain activity in adulthood. Soc Cogn Affect Neurosci 11:405-12
Swartz, J R; Hariri, A R; Williamson, D E (2016) An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents. Mol Psychiatry :
Sorensen, Lucy C; Dodge, Kenneth A; Conduct Problems Prevention Research Group (2016) How Does the Fast Track Intervention Prevent Adverse Outcomes in Young Adulthood? Child Dev 87:429-45
Pek, Jolynn; Hoyle, Rick H (2016) On the (In)Validity of Tests of Simple Mediation: Threats and Solutions. Soc Personal Psychol Compass 10:150-163
Pasalich, Dave S; Witkiewitz, Katie; McMahon, Robert J et al. (2016) Indirect Effects of the Fast Track Intervention on Conduct Disorder Symptoms and Callous-Unemotional Traits: Distinct Pathways Involving Discipline and Warmth. J Abnorm Child Psychol 44:587-97
Wu, Li-Tzy; Swartz, Marvin S; Brady, Kathleen T et al. (2015) Perceived cannabis use norms and cannabis use among adolescents in the United States. J Psychiatr Res 64:79-87
Hopkin, Cameron R; Hoyle, Rick H; Gottfredson, Nisha C (2015) Maximizing the Yield of Small Samples in Prevention Research: A Review of General Strategies and Best Practices. Prev Sci 16:950-5
Dent, Amy L; Hoyle, Rick H (2015) A Framework for Evaluating and Enhancing Alignment in Self-Regulated Learning Research. Metacogn Learn 10:165-179

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