This renewal application proposes the Center for the Study of Adolescent Risk and Resilience (C-StARR). Initially funded in 2003 as a developmental (P20) center, the current cores-only (P30) center supports innovative interdisciplinary research on self-regulation and drug use in late adolescence. Our application for continuing funding as a NIDA P30 Core Center of Excellence describes an ambitious research agenda addressing genetic, neural, and cognitive mechanisms in self-regulation and proposes significant new investments in the collection of imaging, genetic, and biomarker data ("biodata") to supplement behavioral and administrative data in ongoing studies. In order to achieve an overall goal of informing practice and policy, the work of the C-StARR will be guided by four specific aims. First, through its research support cores, the C-StARR will enhance the sampling, methods, and analyses of ongoing studies of adolescent self-regulation and substance use. Investigators have an unprecedented opportunity to analyze comprehensive educational records from the entire population of public school students in North Carolina in order to target specific samples and solicit them for new inquiry. Second, through pilot studies, C-StARR investigators will formulate and test novel hypotheses regarding the interplay of self-regulation and adolescent substance use and abuse. Third, the C-StARR will encourage and support the integration of biological processes with social processes in models of self-regulation. Fourth, support staff and senior investigators will contribute to the training of the next generation of behavioral scientists by integrating early-career faculty members, postdoctoral fellows, and graduate student research teams. The C-StARR will achieve these aims through three cores. The Administrative Core will provide scientific leadership, ensure collaboration and synergy across cores and projects, and lead training efforts. The Data Core will support innovative approaches to sampling, measurement, data collection, and data analysis. And the Biological Methods Support Core will support the addition of biodata to ongoing and pilot research studies by C-StARR investigators. The C-StARR will serve as a national resource for prevention scientists, intervention specialists, and policy makers.
The costs to society of the use and abuse of alcohol, tobacco, and other drugs are among the highest of all conditions targeted by NIH. The proposed center will address this major public health concern by supporting an interdisciplinary team of behavioral scientists to conduct innovative research on the causes and consequences of substance use during late adolescence, the period when substance becomes costly.
|Hoyle, Rick H; Gottfredson, Nisha C (2015) Sample Size Considerations in Prevention Research Applications of Multilevel Modeling and Structural Equation Modeling. Prev Sci 16:987-96|
|Schwartz, David; Lansford, Jennifer E; Dodge, Kenneth A et al. (2015) Peer victimization during middle childhood as a lead indicator of internalizing problems and diagnostic outcomes in late adolescence. J Clin Child Adolesc Psychol 44:393-404|
|Kwak, Youngbin; Pearson, John; Huettel, Scott A (2014) Differential reward learning for self and others predicts self-reported altruism. PLoS One 9:e107621|
|Copeland, William E; Wolke, Dieter; Lereya, Suzet Tanya et al. (2014) Childhood bullying involvement predicts low-grade systemic inflammation into adulthood. Proc Natl Acad Sci U S A 111:7570-5|
|Dodge, Kenneth A; Goodman, W Benjamin; Murphy, Robert A et al. (2014) Implementation and randomized controlled trial evaluation of universal postnatal nurse home visiting. Am J Public Health 104 Suppl 1:S136-43|
|Wu, Li-Tzy; Swartz, Marvin S; Brady, Kathleen T et al. (2014) Nonmedical stimulant use among young Asian-Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals aged 12-34 years in the United States. J Psychiatr Res 59:189-99|
|Shanahan, Lilly; Copeland, William E; Angold, Adrian et al. (2014) Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry 53:550-8|
|Meier, Madeline H; Caspi, Avshalom; Reichenberg, Abraham et al. (2014) Neuropsychological decline in schizophrenia from the premorbid to the postonset period: evidence from a population-representative longitudinal study. Am J Psychiatry 171:91-101|
|Boynton, Marcella H; Richman, Laura Smart (2014) An online daily diary study of alcohol use using Amazon's Mechanical Turk. Drug Alcohol Rev 33:456-61|
|Carré, Justin M; Iselin, Anne-Marie R; Welker, Keith M et al. (2014) Testosterone reactivity to provocation mediates the effect of early intervention on aggressive behavior. Psychol Sci 25:1140-6|
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