The Center for Translational and Prevention Science (CTAPS) was funded in 2009 to inform the development of prevention programs for rural African American youth through investigations of gene environment (G-E) interplay on drug use and HIV-related behavior. The proposed continuation augments CTAPS'scientific agenda to better address racial disparities in drug use and HIV-related behavior that affect rural African Americans. Emerging research suggests that exposure to chronic stress affects the functioning of inflammatory, neuroendocrine, and neurocognitive systems beginning in childhood and adolescence. The negative consequences of chronic stress affect health-related behaviors and forecast chronic diseases of aging. Emerging evidence suggests that these processes also may affect youth and young adults'development of drug misuse and HIV related behavior. The Center will sponsor a new generation of research on (a) the neuroendocrine, inflammatory, and neurocognitive pathways through which exposure to stress among rural African American youth and young adults creates vulnerabilities to drug use and HIV related behavior, (b), the malleable risk and protective processes that affect underlying vulnerability mechanisms , and (c) the translation of findings into new and refined preventive interventions for youth in general and rural African American youth in particular. The CTAPS will pursue these scientific goals via providing infrastructure for three support cores (Inflammation/Neuroendocrine, Neurocognitive, Biostatistics) that will enrich data from data from Core projects and pilot projects and a Pilot Core. CTAPS will facilitate communication among Center-affiliated investigators, support core directors, and core project PIs;oversee administration of Center-wide budgets and operations;provide infrastructure and administrative support for three support cores and a Pilot Core. CTAPS will spur progress via a transdisciplinary work group system designed to facilitate transdisciplinary collaboration and to organize the allocation of Center resources and disseminate research findings to multiple stakeholders including researchers, policy makers, educational organizations, and the public.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Center Core Grants (P30)
Project #
2P30DA027827-06
Application #
8785785
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Crump, Aria
Project Start
2009-12-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Georgia
Department
Psychology
Type
Organized Research Units
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602
Beach, Steven R H; Lei, Man Kit; Simons, Ronald L et al. (2018) MTHFR regulatory effects on methylation of CG05575921 in response to smoking: Effects are also discernable using MTHFR expression. Am J Med Genet B Neuropsychiatr Genet 177:529-534
Hostinar, Camelia E; Nusslock, Robin; Miller, Gregory E (2018) Future Directions in the Study of Early-Life Stress and Physical and Emotional Health: Implications of the Neuroimmune Network Hypothesis. J Clin Child Adolesc Psychol 47:142-156
Barton, Allen W; Beach, Steven R H; Bryant, Chalandra M et al. (2018) Stress spillover, African Americans' couple and health outcomes, and the stress-buffering effect of family-centered prevention. J Fam Psychol 32:186-196
Chen, E; Miller, G E; Yu, T et al. (2018) Unsupportive parenting moderates the effects of family psychosocial intervention on metabolic syndrome in African American youth. Int J Obes (Lond) 42:634-640
Shaffer, Anne; Whitehead, Monica; Davis, Molly et al. (2018) A Model-Based Cluster Analysis of Maternal Emotion Regulation and Relations to Parenting Behavior. Fam Process 57:707-718
Oshri, Assaf; Duprey, Erinn B; Kogan, Steven M et al. (2018) Growth patterns of future orientation among maltreated youth: A prospective examination of the emergence of resilience. Dev Psychol 54:1456-1471
Lei, Man-Kit; Beach, Steven R H; Simons, Ronald L (2018) Biological embedding of neighborhood disadvantage and collective efficacy: Influences on chronic illness via accelerated cardiometabolic age. Dev Psychopathol 30:1797-1815
Zapolski, Tamika C B; Rowe, Alia T; Banks, Devin E et al. (2018) Perceived Discrimination and Substance Use among Adolescents: Examining the Moderating Effect of Distress Tolerance and Negative Urgency. Subst Use Misuse :1-10
Owens, Max M; Amlung, Michael T; Stojek, Monika et al. (2018) Negative urgency moderates reactivity to laboratory stress inductions. J Abnorm Psychol 127:385-393
Barton, Allen W; Yu, Tianyi; Brody, Gene H et al. (2018) Childhood poverty, catecholamines, and substance use among African American young adults: The protective effect of supportive parenting. Prev Med 112:1-5

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