The Center for Translational and Prevention Science (CTAPS) was funded in 2009 to inform the development of prevention programs for rural African American youth through investigations of gene environment (G-E) interplay on drug use and HIV-related behavior. The proposed continuation augments CTAPS'scientific agenda to better address racial disparities in drug use and HIV-related behavior that affect rural African Americans. Emerging research suggests that exposure to chronic stress affects the functioning of inflammatory, neuroendocrine, and neurocognitive systems beginning in childhood and adolescence. The negative consequences of chronic stress affect health-related behaviors and forecast chronic diseases of aging. Emerging evidence suggests that these processes also may affect youth and young adults'development of drug misuse and HIV related behavior. The Center will sponsor a new generation of research on (a) the neuroendocrine, inflammatory, and neurocognitive pathways through which exposure to stress among rural African American youth and young adults creates vulnerabilities to drug use and HIV related behavior, (b), the malleable risk and protective processes that affect underlying vulnerability mechanisms , and (c) the translation of findings into new and refined preventive interventions for youth in general and rural African American youth in particular. The CTAPS will pursue these scientific goals via providing infrastructure for three support cores (Inflammation/Neuroendocrine, Neurocognitive, Biostatistics) that will enrich data from data from Core projects and pilot projects and a Pilot Core. CTAPS will facilitate communication among Center-affiliated investigators, support core directors, and core project PIs;oversee administration of Center-wide budgets and operations;provide infrastructure and administrative support for three support cores and a Pilot Core. CTAPS will spur progress via a transdisciplinary work group system designed to facilitate transdisciplinary collaboration and to organize the allocation of Center resources and disseminate research findings to multiple stakeholders including researchers, policy makers, educational organizations, and the public.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Center Core Grants (P30)
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Special Emphasis Panel (ZDA1)
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Crump, Aria
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University of Georgia
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United States
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Beach, Steven R H; Lei, Man Kit; Simons, Ronald L et al. (2018) MTHFR regulatory effects on methylation of CG05575921 in response to smoking: Effects are also discernable using MTHFR expression. Am J Med Genet B Neuropsychiatr Genet 177:529-534
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Chen, E; Miller, G E; Yu, T et al. (2018) Unsupportive parenting moderates the effects of family psychosocial intervention on metabolic syndrome in African American youth. Int J Obes (Lond) 42:634-640
Shaffer, Anne; Whitehead, Monica; Davis, Molly et al. (2018) A Model-Based Cluster Analysis of Maternal Emotion Regulation and Relations to Parenting Behavior. Fam Process 57:707-718
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Zapolski, Tamika C B; Rowe, Alia T; Banks, Devin E et al. (2018) Perceived Discrimination and Substance Use among Adolescents: Examining the Moderating Effect of Distress Tolerance and Negative Urgency. Subst Use Misuse :1-10
Owens, Max M; Amlung, Michael T; Stojek, Monika et al. (2018) Negative urgency moderates reactivity to laboratory stress inductions. J Abnorm Psychol 127:385-393
Barton, Allen W; Yu, Tianyi; Brody, Gene H et al. (2018) Childhood poverty, catecholamines, and substance use among African American young adults: The protective effect of supportive parenting. Prev Med 112:1-5

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