The Center for Translational and Prevention Science (CTAPS) was funded in 2009 to inform the development of prevention programs for rural African American youth through investigations of gene environment (G-E) interplay on drug use and HIV-related behavior. The proposed continuation augments CTAPS'scientific agenda to better address racial disparities in drug use and HIV-related behavior that affect rural African Americans. Emerging research suggests that exposure to chronic stress affects the functioning of inflammatory, neuroendocrine, and neurocognitive systems beginning in childhood and adolescence. The negative consequences of chronic stress affect health-related behaviors and forecast chronic diseases of aging. Emerging evidence suggests that these processes also may affect youth and young adults'development of drug misuse and HIV related behavior. The Center will sponsor a new generation of research on (a) the neuroendocrine, inflammatory, and neurocognitive pathways through which exposure to stress among rural African American youth and young adults creates vulnerabilities to drug use and HIV related behavior, (b), the malleable risk and protective processes that affect underlying vulnerability mechanisms , and (c) the translation of findings into new and refined preventive interventions for youth in general and rural African American youth in particular. The CTAPS will pursue these scientific goals via providing infrastructure for three support cores (Inflammation/Neuroendocrine, Neurocognitive, Biostatistics) that will enrich data from data from Core projects and pilot projects and a Pilot Core. CTAPS will facilitate communication among Center-affiliated investigators, support core directors, and core project PIs;oversee administration of Center-wide budgets and operations;provide infrastructure and administrative support for three support cores and a Pilot Core. CTAPS will spur progress via a transdisciplinary work group system designed to facilitate transdisciplinary collaboration and to organize the allocation of Center resources and disseminate research findings to multiple stakeholders including researchers, policy makers, educational organizations, and the public.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Center Core Grants (P30)
Project #
2P30DA027827-06
Application #
8785785
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Crump, Aria
Project Start
2009-12-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Georgia
Department
Psychology
Type
Organized Research Units
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602
Beach, Steven R H; Lei, Man Kit; Brody, Gene H et al. (2016) Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation. Prev Sci :
Suveg, Cynthia; Shaffer, Anne; Davis, Molly (2016) Family stress moderates relations between physiological and behavioral synchrony and child self-regulation in mother-preschooler dyads. Dev Psychobiol 58:83-97
Brody, Gene H; Miller, Gregory E; Yu, Tianyi et al. (2016) Supportive Family Environments Ameliorate the Link Between Racial Discrimination and Epigenetic Aging: A Replication Across Two Longitudinal Cohorts. Psychol Sci 27:530-41
Brody, Gene H; Yu, Tianyi; Beach, Steven R H (2016) Resilience to adversity and the early origins of disease. Dev Psychopathol 28:1347-1365
Gray, Joshua C; Amlung, Michael T; Palmer, Abraham A et al. (2016) Syntax for calculation of discounting indices from the monetary choice questionnaire and probability discounting questionnaire. J Exp Anal Behav 106:156-63
Brody, Gene H; Yu, Tianyi; Chen, Edith et al. (2016) Family-centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging. J Child Psychol Psychiatry 57:566-74
Brody, Gene H; Yu, Tianyi; Barton, Allen W et al. (2016) Youth temperament, harsh parenting, and variation in the oxytocin receptor gene forecast allostatic load during emerging adulthood. Dev Psychopathol :1-13
Chen, Edith; Miller, Gregory E; Yu, Tianyi et al. (2016) The Great Recession and health risks in African American youth. Brain Behav Immun 53:234-41
Dogan, Meeshanthini V; Lei, Man-Kit; Beach, Steven R H et al. (2016) Alcohol and tobacco consumption alter hypothalamic pituitary adrenal axis DNA methylation. Psychoneuroendocrinology 66:176-84
Sales, Jessica M; Swartzendruber, Andrea; Phillips, Ashley L (2016) Trauma-Informed HIV Prevention and Treatment. Curr HIV/AIDS Rep 13:374-382

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