Hearing loss is the most frequent sensory defect in humans. Congenital, perinatal or eariy onset hearing loss occurs in approximately 7 out of 1000 neonates in the United States. In approximately half of the children born with severe hearing impairment, a genetic contribution is suspected. The powerful molecular and genetic techniques available in zebrafish and mouse combined with the functional similarities between mouse and human audition make these organism useful model systems for studying deafness. Core D supports users of genetic models to study genes affecting auditory, vestibular and olfactory system function. We provide technical support in the form of expert mouse husbandry (receiving, setting up crosses, weaning, fostering, background transfers, etc), genotyping, and notification/delivery of requested mice to the users. Core D also supports several facilities for behavioral and physiological analyses of mutants including auditory brainstem responses (ABR), simple motor tests, rotarod testing, and vestibulo-ocular reflex (VOR) analysis. Other services include access to lentiviral transfection technologies and resources for genomic and proteomic data analysis. Advice and training is available to all users from a knowledgeable and helpful Core staff. The Genetics Core will provide greater efficiency for researchers and promote new collaborations between investigators. Quarteriy user meetings provide information on Core resources, discussion of protocols, and talks by Core users on their own research projects currently being pursued. Our goal is to facilitate the use of genetic models to broaden our knowledge of communicafive disorders toward improving human health.

Public Health Relevance

Increasing the efficiency and efficacy of research on hearing, communication and balance will help, in the short term, bring new therapies to the bedside. In the long term, better understanding of the basic normal operation of the organs and systems underiying these functions, as well as the processes leading to disorders, is likely to lead to better prevention and treatment of such disorders and to improved human health.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC004661-14
Application #
8526216
Study Section
Special Emphasis Panel (ZDC1-SRB-Q)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
14
Fiscal Year
2013
Total Cost
$138,907
Indirect Cost
$49,864
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Stone, Jennifer S; Wisner, Serena R; Bucks, Stephanie A et al. (2018) Characterization of Adult Vestibular Organs in 11 CreER Mouse Lines. J Assoc Res Otolaryngol 19:381-399
Daliri, Ayoub; Max, Ludo (2018) Stuttering adults' lack of pre-speech auditory modulation normalizes when speaking with delayed auditory feedback. Cortex 99:55-68
Lewis, Rebecca M; Keller, Jesse J; Wan, Liangcai et al. (2018) Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium. Hear Res 364:1-11
Maruthy, Santosh; Feng, Yongqiang; Max, Ludo (2018) Spectral Coefficient Analyses of Word-Initial Stop Consonant Productions Suggest Similar Anticipatory Coarticulation for Stuttering and Nonstuttering Adults. Lang Speech 61:31-42
Wu, Yu-Hsiang; Dumanch, Kelsey; Stangl, Elizabeth et al. (2017) Is the Device-Oriented Subjective Outcome (DOSO) Independent of Personality? J Am Acad Audiol 28:932-940
Bucks, Stephanie A; Cox, Brandon C; Vlosich, Brittany A et al. (2017) Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice. Elife 6:
Miller, Christi W; Bentler, Ruth A; Wu, Yu-Hsiang et al. (2017) Output signal-to-noise ratio and speech perception in noise: effects of algorithm. Int J Audiol 56:568-579
Miller, Christi W; Stewart, Erin K; Wu, Yu-Hsiang et al. (2017) Working Memory and Speech Recognition in Noise Under Ecologically Relevant Listening Conditions: Effects of Visual Cues and Noise Type Among Adults With Hearing Loss. J Speech Lang Hear Res 60:2310-2320
Horn, David L; Won, Jong Ho; Rubinstein, Jay T et al. (2017) Spectral Ripple Discrimination in Normal-Hearing Infants. Ear Hear 38:212-222
Miller, Christi W; Baylor, Carolyn R; Birch, Kristen et al. (2017) Exploring the Relevance of Items in the Communicative Participation Item Bank (CPIB) for Individuals With Hearing Loss. Am J Audiol 26:27-37

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