Hearing loss is the most frequent sensory defect in humans. Congenital, perinatal or eariy onset hearing loss occurs in approximately 7 out of 1000 neonates in the United States. In approximately half of the children born with severe hearing impairment, a genetic contribution is suspected. The powerful molecular and genetic techniques available in zebrafish and mouse combined with the functional similarities between mouse and human audition make these organism useful model systems for studying deafness. Core D supports users of genetic models to study genes affecting auditory, vestibular and olfactory system function. We provide technical support in the form of expert mouse husbandry (receiving, setting up crosses, weaning, fostering, background transfers, etc), genotyping, and notification/delivery of requested mice to the users. Core D also supports several facilities for behavioral and physiological analyses of mutants including auditory brainstem responses (ABR), simple motor tests, rotarod testing, and vestibulo-ocular reflex (VOR) analysis. Other services include access to lentiviral transfection technologies and resources for genomic and proteomic data analysis. Advice and training is available to all users from a knowledgeable and helpful Core staff. The Genetics Core will provide greater efficiency for researchers and promote new collaborations between investigators. Quarteriy user meetings provide information on Core resources, discussion of protocols, and talks by Core users on their own research projects currently being pursued. Our goal is to facilitate the use of genetic models to broaden our knowledge of communicafive disorders toward improving human health.

Public Health Relevance

Increasing the efficiency and efficacy of research on hearing, communication and balance will help, in the short term, bring new therapies to the bedside. In the long term, better understanding of the basic normal operation of the organs and systems underiying these functions, as well as the processes leading to disorders, is likely to lead to better prevention and treatment of such disorders and to improved human health.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30DC004661-15
Application #
8716721
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
Esterberg, Robert; Linbo, Tor; Pickett, Sarah B et al. (2016) Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death. J Clin Invest 126:3556-66
Cramer, Karina S; Rubel, Edwin W (2016) Glial Cell Contributions to Auditory Brainstem Development. Front Neural Circuits 10:83
Miller, Christi W; Bates, Emily; Brennan, Marc (2016) The effects of frequency lowering on speech perception in noise with adult hearing-aid users. Int J Audiol 55:305-12
Slowik, Amber D; Bermingham-McDonogh, Olivia (2016) A central to peripheral progression of cell cycle exit and hair cell differentiation in the developing mouse cristae. Dev Biol 411:1-14
Seidl, Armin H; Rubel, Edwin W (2016) Systematic and differential myelination of axon collaterals in the mammalian auditory brainstem. Glia 64:487-94
Drennan, Ward R; Won, Jong Ho; Timme, Alden O et al. (2016) Nonlinguistic Outcome Measures in Adult Cochlear Implant Users Over the First Year of Implantation. Ear Hear 37:354-64
Chun, Ingyu; Billings, Curtis J; Miller, Christi W et al. (2016) Aided Electrophysiology Using Direct Audio Input: Effects of Amplification and Absolute Signal Level. Am J Audiol 25:14-24
Daliri, Ayoub; Max, Ludo (2016) Modulation of Auditory Responses to Speech vs. Nonspeech Stimuli during Speech Movement Planning. Front Hum Neurosci 10:234
Bierer, Julie A; Litvak, Leonid (2016) Reducing Channel Interaction Through Cochlear Implant Programming May Improve Speech Perception: Current Focusing and Channel Deactivation. Trends Hear 20:
Luo, Chuan; Omelchenko, Irina; Manson, Robert et al. (2015) Direct Intracochlear Acoustic Stimulation Using a PZT Microactuator. Trends Hear 19:

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