HUMAN RESEARCH SUBJECTS CORE Subject recruitment influences research productivity and the pace of research. There are, however, barriers to efficient subject recruitment. In general, few contacted individuals participate in research, with even lower participation among minority communities. Regulatory changes result in additional barriers to subject recruitment. Ensuring compliance with regulations related to human research detracts from time engaged in research. The overarching goal of the Human Research Subjects Core (HRSC), to increase productivity and the pace of research for programs that involve human subjects, is achieved through three mechanisms: (1) increase subject-recruitment efficiency, with special attention to minority-subject recruitment, (2) assist investigators with quality-assurance evaluations, ensure compliance with regulations, and provide a secure environment in which consent/assent/HlPAA forms are stored, and (3) assist investigators in the preparation of IRB and NIH progress reports, IRB applications, and enrollment forms for NIH applications. These services are designed to increase productivity by allowing PIs to focus more on research while assuring that they are in compliance with regulations governing the use of human subjects. With the assistance of the HRSC, 70% of contacted individuals now participate as research subjects. Minority representation in research studies now approximates their representation in our catchment area. Many mechanisms have been put into place that alleviate administrative burdens and ensure compliance. New to the coming cycle, HRSC staff will (1) provide audiometric, tympanometric, and speech-language testing for individuals in the database for whom information is not available, (2) provide these services to research programs that do not have staff qualified to perform these evaluations, and (3) provide consentprocess evaluations by having the HRSC Coordinator observe the consenting of subjects for IRB-approved protocols. The combination of HRSC services will increase both productivity and the pace of research for NIDCD-funded programs that involve humans as subjects.

Public Health Relevance

Research productivity and the pace of research depend on the efficiency with which subjects can be recruited. Human research must pay careful attention to regulations designed to protect the rights of subjects. The HRSC meets these needs by providing access to a diverse group of subjects, increasing participation in both majority and minority communities, and ensuring compliance with regulations governing the use of human subjects.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
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Father Flanagan's Boys' Home
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Trevino, Andrea C; Jesteadt, Walt; Neely, Stephen T (2016) Modeling the Individual Variability of Loudness Perception with a Multi-Category Psychometric Function. Adv Exp Med Biol 894:155-64
García, Paula B; Rosado Rogers, Lydia; Nishi, Kanae (2016) Testing Speech Recognition in Spanish-English Bilingual Children with the Computer-Assisted Speech Perception Assessment (CASPA): Initial Report. Ear Hear 37:492-4
Brennan, Marc; McCreery, Ryan; Kopun, Judy et al. (2016) Masking Release in Children and Adults With Hearing Loss When Using Amplification. J Speech Lang Hear Res 59:110-21
Sieck, Nicole E; Rasetshwane, Daniel M; Kopun, Judy G et al. (2016) Multi-tone suppression of distortion-product otoacoustic emissions in humans. J Acoust Soc Am 139:2299
Trevino, Andrea C; Jesteadt, Walt; Neely, Stephen T (2016) Development of a multi-category psychometric function to model categorical loudness measurements. J Acoust Soc Am 140:2571
Baudhuin, Jacquelyn L; Hughes, Michelle L; Goehring, Jenny L (2016) A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential. Ear Hear 37:e247-55
Joshi, Suyash Narendra; Wróblewski, Marcin; Schmid, Kendra K et al. (2016) Effects of relative and absolute frequency in the spectral weighting of loudness. J Acoust Soc Am 139:373-83
VanDam, Mark; Oller, D Kimbrough; Ambrose, Sophie E et al. (2015) Automated Vocal Analysis of Children With Hearing Loss and Their Typical and Atypical Peers. Ear Hear 36:e146-52
Hughes, Michelle L; Baudhuin, Jacquelyn L; Goehring, Jenny L (2015) Effect of electrode impedance on spread of excitation and pitch perception using electrically coupled ""dual-electrode"" stimulation. Ear Hear 36:e50-6
Brennan, Marc A; McCreery, Ryan W; Jesteadt, Walt (2015) The influence of hearing-aid compression on forward-masked thresholds for adults with hearing loss. J Acoust Soc Am 138:2589-97

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