Public Health Relevance

The gene revolution has led to the creation of a vast number of transgenic and gene knockout rodent models. These represent a virtual goldmine for new insights into sensory function and dysfunction, but that potential can only be realized if new models are comprehensively examined both anatomically and functionally. The Functional Testing Core promotes thorough and rigorous functional analysis of inner ear and visual function so that the value for public health of new animal models can be fully realized.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
2P30DC004665-11
Application #
8125645
Study Section
Special Emphasis Panel (ZDC1-SRB-Q (64))
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
11
Fiscal Year
2011
Total Cost
$200,631
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Kao, Wee Tin K; Parnes, Lorne S; Chole, Richard A (2017) Otoconia and otolithic membrane fragments within the posterior semicircular canal in benign paroxysmal positional vertigo. Laryngoscope 127:709-714
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Kim, Alfred Hj; Chung, Jun-Jae; Akilesh, Shreeram et al. (2017) B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement. JCI Insight 2:
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Graboyes, Evan M; Townsend, Melanie E; Kallogjeri, Dorina et al. (2016) Evaluation of Quality Metrics for Surgically Treated Laryngeal Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg 142:1154-1163
Youm, Ibrahima; Musazzi, Umberto M; Gratton, Michael Anne et al. (2016) Label-Free Ferrocene-Loaded Nanocarrier Engineering for In Vivo Cochlear Drug Delivery and Imaging. J Pharm Sci 105:3162-3171
Meehan, Daniel T; Delimont, Duane; Dufek, Brianna et al. (2016) Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. Hear Res 341:100-108
Rakszawski, Bernadette; Wright, Rose; Cadieux, Jamie H et al. (2016) The Effects of Preprocessing Strategies for Pediatric Cochlear Implant Recipients. J Am Acad Audiol 27:85-102

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