Public Health Relevance

The gene revolution has led to the creation of a vast number of transgenic and gene knockout rodent models. These represent a virtual goldmine for new insights into sensory function and dysfunction, but that potential can only be realized if new models are comprehensively examined both anatomically and functionally. The Functional Testing Core promotes thorough and rigorous functional analysis of inner ear and visual function so that the value for public health of new animal models can be fully realized.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
2P30DC004665-11
Application #
8125645
Study Section
Special Emphasis Panel (ZDC1-SRB-Q (64))
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
11
Fiscal Year
2011
Total Cost
$200,631
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Meehan, Daniel T; Delimont, Duane; Dufek, Brianna et al. (2016) Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. Hear Res 341:100-108
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Dufek, Brianna; Meehan, Daniel T; Delimont, Duane et al. (2016) Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease. Kidney Int 90:300-10
Kaur, Tejbeer; Zamani, Darius; Tong, Ling et al. (2015) Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion. J Neurosci 35:15050-61
Huh, Sung-Ho; Warchol, Mark E; Ornitz, David M (2015) Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. Elife 4:
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de la Puente, Pilar; Muz, Barbara; Gilson, Rebecca C et al. (2015) 3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma. Biomaterials 73:70-84
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