This application requests support to continue the productive work of the University of Michigan Cell &Molecular Biology (CMB) Core to enhance NIDCD-mission oriented research. The proposal builds on experience gained from the two previous P30 grant periods The Cell &Molecular Biology (CMB) Core will continue to serve the user base through its four aims:
Aim 1 : Enhance and extend the quality and scope of the individual research projects of Core participants Aim 2: Improve efficiency and productivity of research within the user group Aim 3: Develop methods and approaches to meet current user needs and to anticipate future needs Aim 4: Provide education, develop collaborations and bring new people into the field New to the next five years, the CMB Core is adding processing and assessment of vestibular tissues and tissues associated with the chemical senses, to reflect the needs of the user base. Dr. Kohrman is replacing Dr. Lomax as the co-Director and the molecular biology consultation offered can expand to include information on developing and using transgenic mice. The CMB will continue to bring new methods and approaches to individual investigators and develop technology, data bases and shared resources. It will provide information on new advances in methodology to individual investigators, train staff of individual investigators in both routine and novel molecular methodologies and provide a bridge to centralized University of Michigan facilities for novel and advanced methodologies. It will provide state-of-the-art support for morphological and molecular assessments, provide normative data bases and provide assistance in experimental design and interpretation of results. It will use the Scientific Synergy Core and periodic meetings with qualified users to present new methods and approaches, share experiences, problems and successes and develop new productive collaborations. The CMB services and presentations will continue to bring new investigators to the study of hearing, balance and chemical senses research. The CMB Core will also work closely with the Physiology Core to coordinate physiological, behavioral, morphological and molecular characterization of animals to enhance our understanding of hearing, balance and chemical senses and to define molecular interventions that will prevent and treat their disorders.

Public Health Relevance

The purpose of this grant is to enhance and extend the research of multiple investigators towards increasing the understanding of disorders of hearing, balance, taste and smell and developing the ability to prevent and treat these disorders. It will also provide mechanisms to encourage and increase collaborations among its research base, bring new researchers into the field as well as educate the user base on new methods and approaches.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDC1-SRB-L)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Choo, Daniel I; Tawfik, Kareem O; Martin, Donna M et al. (2017) Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures. Am J Med Genet C Semin Med Genet 175:439-449
Yang, Chao-Hui; Liu, Zhiqi; Dong, Deanna et al. (2017) Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Front Cell Neurosci 11:315
Walline, Heather M; Goudsmit, Christine M; McHugh, Jonathan B et al. (2017) Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines. Head Neck 39:840-852
Schaefer, Stacy A; Higashi, Atsuko Y; Loomis, Benjamin et al. (2017) From otic induction to hair cell production: Pax2EGFP cell line illuminates key stages of development in mouse inner ear organoid model. Stem Cells Dev :
Munnamalai, Vidhya; Sienknecht, Ulrike J; Duncan, R Keith et al. (2017) Wnt9a Can Influence Cell Fates and Neural Connectivity across the Radial Axis of the Developing Cochlea. J Neurosci 37:8975-8988
Schvartz-Leyzac, Kara C; Pfingst, Bryan E (2017) Assessing the Relationship Between the Electrically Evoked Compound Action Potential and Speech Recognition Abilities in Bilateral Cochlear Implant Recipients. Ear Hear :
Morley, Barbara J; Dolan, David F; Ohlemiller, Kevin K et al. (2017) Generation and Characterization of ?9 and ?10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background. Front Neurosci 11:516
Pfingst, Bryan E; Colesa, Deborah J; Swiderski, Donald L et al. (2017) Neurotrophin Gene Therapy in Deafened Ears with Cochlear Implants: Long-term Effects on Nerve Survival and Functional Measures. J Assoc Res Otolaryngol 18:731-750
Schvartz-Leyzac, Kara C; Zwolan, Teresa A; Pfingst, Bryan E (2017) Effects of electrode deactivation on speech recognition in multichannel cochlear implant recipients. Cochlear Implants Int 18:324-334
Klimpel, Katarina E M; Lee, Min Young; King, W. Michael et al. (2017) Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment. Environ Toxicol 32:869-876

Showing the most recent 10 out of 278 publications