This application requests support to continue the productive work of the Hearing, Balance and Chemical Senses Research Core Center to enhance the quality and scope of NIDCD-mission oriented research. The proposal builds on experience gained from the two previous P30 grant periods including the successful introduction of the Scientific Synergy Core (Core A) a novel approach to foster interactions and collaborations among scientists at the University of Michigan, Michigan State University, Wayne State University, and University of Toledo. A new development is a broadening of the Core, adding services in the vestibular system and the chemical senses and bringing in investigators studying speech and language pathology. Investigators will continue to be supported by two scientific cores offering resources, training, and services in physiology and behavior (Core B) and cell and molecular biology (Core C). The Instrument Design and Technical Services Core (Core D) will design and manufacture specialized electronic and mechanical instruments as well as consult in computing-related issues. Cores will be supervised by expert core directors and staffed with experienced personnel. The key aims across all the Cores remain to:
Aim 1 : Enhance and extend the quality and scope of the individual research projects of Core participants.
Aim 2 : Improve efficiency and productivity of research within the user group.
Aim 3 : Develop methods and approaches to meet current user needs and to anticipate future needs.
Aim 4 : Provide education, develop collaborations and bring new people into the field. Within the intellectual environment generated by the Scientific Synergy Core and the availability of these resources, this Center will promote interactions and multidisciplinary research by providing novel methodologies, standardized analytical tools, and the exchange of technological experience. It will continue to generate new users and collaborations attracted by the Core services and interactions. Regular meetings of the core users, the affinity groups, and the entire Center research community will assure the best possible implementation of collaborations and effective use of research support.

Public Health Relevance

The purpose of this grant is to enhance and extend the research of multiple investigators towards increasing the understanding of disorders of hearing, balance, taste and smell and developing the ability to prevent and treat these disorders. It will also provide mechanisms to encourage and increase collaborations among its research base, bring new researchers into the field as well as educate the user base on new methods and approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005188-13
Application #
8696840
Study Section
Special Emphasis Panel (ZDC1)
Program Officer
Platt, Christopher
Project Start
2002-01-01
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Choo, Daniel I; Tawfik, Kareem O; Martin, Donna M et al. (2017) Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures. Am J Med Genet C Semin Med Genet 175:439-449
Yang, Chao-Hui; Liu, Zhiqi; Dong, Deanna et al. (2017) Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Front Cell Neurosci 11:315
Walline, Heather M; Goudsmit, Christine M; McHugh, Jonathan B et al. (2017) Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines. Head Neck 39:840-852
Schaefer, Stacy A; Higashi, Atsuko Y; Loomis, Benjamin et al. (2017) From otic induction to hair cell production: Pax2EGFP cell line illuminates key stages of development in mouse inner ear organoid model. Stem Cells Dev :
Munnamalai, Vidhya; Sienknecht, Ulrike J; Duncan, R Keith et al. (2017) Wnt9a Can Influence Cell Fates and Neural Connectivity across the Radial Axis of the Developing Cochlea. J Neurosci 37:8975-8988
Schvartz-Leyzac, Kara C; Pfingst, Bryan E (2017) Assessing the Relationship Between the Electrically Evoked Compound Action Potential and Speech Recognition Abilities in Bilateral Cochlear Implant Recipients. Ear Hear :
Morley, Barbara J; Dolan, David F; Ohlemiller, Kevin K et al. (2017) Generation and Characterization of ?9 and ?10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background. Front Neurosci 11:516
Pfingst, Bryan E; Colesa, Deborah J; Swiderski, Donald L et al. (2017) Neurotrophin Gene Therapy in Deafened Ears with Cochlear Implants: Long-term Effects on Nerve Survival and Functional Measures. J Assoc Res Otolaryngol 18:731-750
Schvartz-Leyzac, Kara C; Zwolan, Teresa A; Pfingst, Bryan E (2017) Effects of electrode deactivation on speech recognition in multichannel cochlear implant recipients. Cochlear Implants Int 18:324-334
Klimpel, Katarina E M; Lee, Min Young; King, W. Michael et al. (2017) Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment. Environ Toxicol 32:869-876

Showing the most recent 10 out of 278 publications